2,4-Pyrimidinediamine, N2-[3-fluoro-4-(1-piperazinyl)phenyl]-N4-(8-methyl-4-cinnolinyl)- manufacturers
- ALK5-IN-31
-
- $1520.00
-
2026-07-27
- CAS:2785430-87-5
- Purity:
- Supply Ability: 10g
|
| | 2,4-Pyrimidinediamine, N2-[3-fluoro-4-(1-piperazinyl)phenyl]-N4-(8-methyl-4-cinnolinyl)- Basic information |
| | 2,4-Pyrimidinediamine, N2-[3-fluoro-4-(1-piperazinyl)phenyl]-N4-(8-methyl-4-cinnolinyl)- Chemical Properties |
| Boiling point | 685.8±65.0 °C(Predicted) | | density | 1.356±0.06 g/cm3(Predicted) | | pka | 8.76±0.10(Predicted) |
| | 2,4-Pyrimidinediamine, N2-[3-fluoro-4-(1-piperazinyl)phenyl]-N4-(8-methyl-4-cinnolinyl)- Usage And Synthesis |
| Uses | ALK5-IN-31 (compound Ex-08) is a selective ALK-5 inhibitor (IC50≤10 nM), inhibits TGF-β-induced SMAD signaling. ALK5-IN-31 has the potential to inhibit growth of tumour in vivo. ALK5-IN-31 can be used in study of proliferative diseases such as cancer, fibrotic diseases, and systemic sclerosis[1]. | | References | [1] Bettina FRANZ, et al. Alk-5 inhibitors and uses thereof. Patent WO2022126133A1. |
| | 2,4-Pyrimidinediamine, N2-[3-fluoro-4-(1-piperazinyl)phenyl]-N4-(8-methyl-4-cinnolinyl)- Preparation Products And Raw materials |
|