L-Arginine, glycyl-L-valyl-L-seryl-L-tryptophylglycyl-L-leucyl- manufacturers
- PE-22-28
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- $30.00/ kit
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2025-05-27
- CAS:1801959-12-5
- Min. Order: 1kit
- Purity: 99%
- Supply Ability: 10000kits
- PE 22-28
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- $120.00 / 1KG
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2025-03-21
- CAS:1801959-12-5
- Min. Order: 1KG
- Purity: 99.9%
- Supply Ability: 100kg
- PE22-28
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- $300.00 / 1Box
-
2024-11-27
- CAS:1801959-12-5
- Min. Order: 1Box
- Purity: 99%
- Supply Ability: 62222
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| | L-Arginine, glycyl-L-valyl-L-seryl-L-tryptophylglycyl-L-leucyl- Basic information |
| | L-Arginine, glycyl-L-valyl-L-seryl-L-tryptophylglycyl-L-leucyl- Chemical Properties |
| density | 1.44±0.1 g/cm3(Predicted) | | form | Solid | | pka | 3.34±0.10(Predicted) | | color | White to off-white | | InChIKey | CMNBQRXBBJQIOA-YIHYGEMESA-N | | SMILES | C(O)(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CC1C2=C(C=CC=C2)NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](C(C)C)NC(=O)CN |
| | L-Arginine, glycyl-L-valyl-L-seryl-L-tryptophylglycyl-L-leucyl- Usage And Synthesis |
| Uses | PE 22-28 is a TREK-1 inhibitor with IC50 value of 0.12 nM. PE 22-28 also is a 7 amino-acid peptide that is used as a core sequence for preparing analogs by chemical modifications and also by substitution of amino-acids. PE 22-28 can be used for the research of depression[1]. | | in vivo | PE 22-28 (i.p.; 3.0μg/kg) shows antidepressant property[1]. | Animal Model: | Na?ve male C57Bl/6J mice[1] | | Dosage: | 3.0μg/kg | | Administration: | Intraperitoneal | | Result: | Showed a significant reduction of the immobility time, reduced significantly the latency to eat the food pellet, induced neurogenesis and improved the action duration. |
| | References | [1] Alaeddine Djillani, et al. Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity. Front Pharmacol. 2017 Sep 12;8:643. DOI:10.3389/fphar.2017.00643 |
| | L-Arginine, glycyl-L-valyl-L-seryl-L-tryptophylglycyl-L-leucyl- Preparation Products And Raw materials |
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