1H-1,2,3-Triazole-4-carboxamide, 1-cyclopropyl-N-[1-[[1-(phenylmethyl)-1H-pyrazol-4-yl]methyl]-3-azetidinyl]- manufacturers
- EPZ032597
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- $350.00
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2026-07-14
- CAS:1887193-58-9
- Purity: 99.97%
- Supply Ability: 10g
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| | 1H-1,2,3-Triazole-4-carboxamide, 1-cyclopropyl-N-[1-[[1-(phenylmethyl)-1H-pyrazol-4-yl]methyl]-3-azetidinyl]- Basic information |
| | 1H-1,2,3-Triazole-4-carboxamide, 1-cyclopropyl-N-[1-[[1-(phenylmethyl)-1H-pyrazol-4-yl]methyl]-3-azetidinyl]- Chemical Properties |
| density | 1.44±0.1 g/cm3(Predicted) | | pka | 12.93±0.20(Predicted) |
| | 1H-1,2,3-Triazole-4-carboxamide, 1-cyclopropyl-N-[1-[[1-(phenylmethyl)-1H-pyrazol-4-yl]methyl]-3-azetidinyl]- Usage And Synthesis |
| Uses | EPZ032597 is a selective and noncompetitive SMYD2 inhibitor with an IC50 value of 16 nM. EPZ032597 is promising for research of pancreatic ductal adenocarcinoma[1][2]. | | References | [1] Alshammari E, et al. Mechanistic and functional extrapolation of SET and MYND domain-containing protein 2 to pancreatic cancer. World J Gastroenterol. 2022 Aug 7;28(29):3753-3766. DOI:10.3748/wjg.v28.i29.3753 [2] Thomenius MJ, et al. Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation. PLoS One. 2018 Jun 1;13(6):e0197372. DOI:10.1371/journal.pone.0197372 |
| | 1H-1,2,3-Triazole-4-carboxamide, 1-cyclopropyl-N-[1-[[1-(phenylmethyl)-1H-pyrazol-4-yl]methyl]-3-azetidinyl]- Preparation Products And Raw materials |
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