| Company Name: |
TargetMol Chemicals Inc.
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15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:Ro 18-3981
CAS:103295-92-7
Package:25mg/RMB 10600;100mg/RMB 17500;50mg/RMB 13800
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| Company Name: |
CHEMICAL LAND21
|
| Tel: |
82- 2 -783 - 8063 |
| Email: |
sales21@chemicalland21.com |
| Products Intro: |
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Ro 18-3981 manufacturers
- Ro 18-3981
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- $1520.00 / 25mg
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2024-10-28
- CAS:103295-92-7
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | Ro 18-3981 Basic information |
| Product Name: | Ro 18-3981 | | Synonyms: | Ro 18-3981;1,4-Dihydro-2,6-dimethyl-5-[[[(1-methylethyl)amino]sulfonyl]acetyl]-4-(3-nitrophenyl)-3-pyridinecarboxylic acid 2-propoxyethyl ester | | CAS: | 103295-92-7 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | 103295-92-7.mol |  |
| | Ro 18-3981 Chemical Properties |
| | Ro 18-3981 Usage And Synthesis |
| Description | Ro 18-3981 inhibits myocardial Ca2+ channels. The KD value of Ro 18-3981 (1.0 nM) was similar to the IC50 value for blockade of ICa at a Vh of -20 mV (2.3 nM), i.e. at a level of near-maximal depolarization. | | Uses | Ro 18-3981 is a dihydropyridine that inhibits cardiac Ca2+ channels. Ro 18-3981 shows higher inhibitory activity when the cell membrane is in a depolarized state (Vh=-20 mV: IC50=2.3 nM; Vh=-50 mV: IC50=100 nM)[1]. | | References | [1] Holck M, et al. Inhibition of myocardial Ca2+ channels by three dihydropyridines with different structural features: potential‐dependent blockade by Ro 18–3981[J]. British journal of pharmacology, 1987, 91(1): 61-67. DOI:10.1111/j.1476-5381.1987.tb08983.x |
| | Ro 18-3981 Preparation Products And Raw materials |
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