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Nanjing Typeptide Biotechnology Co.,Ltd. Gold
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19961912513; 19941518170 |
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sales@typeptide.com |
| Products Intro: |
Product Name:Ecnoglutide
CAS:2459531-73-6
Purity:98%HPLC Package:1mg/1500;10mg/2000;100mg/5500
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Ecnoglutide manufacturers
- Ecnoglutide
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2026-07-31
- CAS:2459531-73-6
- Min. Order: 1kg
- Purity: 98
- Supply Ability: 1000kgs
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| | Ecnoglutide Basic information |
| Product Name: | Ecnoglutide | | Synonyms: | Ecnoglutide;L-Histidyl-L-valyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-α-glutamyl-L-α-glutamyl-L-glutaminyl-L-alanyl-L-alanyl-L-arginyl-L-α-glutamyl-L-phenylalanyl-L-isoleucyl-N6-[N-(17-carboxy-1-oxoheptadecyl)-L-γ-glutamyl-2-[2-(2-aminoethoxy)ethoxy]acetyl-2-[2-(2-aminoethoxy)ethoxy]acetyl]-L-lysyl-L-tryptophyl-L-leucyl-L-valyl-L-arginylglycyl-L-arginylglycine (ACI) | | CAS: | 2459531-73-6 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![Ecnoglutide Structure]() |
| | Ecnoglutide Chemical Properties |
| solubility | DMSO: Sparingly soluble: 1-10 mg/ml | | form | Solid | | color | White to off-white | | Sequence | His-Val-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Glu-Gln-Ala-Ala-Arg-Glu-Phe-Ile-Lys-(AEEA-AEEA-{γ-Glu}-C18 diacid)-Trp-Leu-Val-Arg-Gly-Arg-Gly |
| | Ecnoglutide Usage And Synthesis |
| Uses | Ecnoglutide (XW003) is a long-acting, cAMP-biased glucagon-like peptide 1 (GLP-1) receptor agonist. Ecnoglutide can be used for research of T2DM and obesity[1][2]. | | in vivo | Ecnoglutide (0.015, 0.15 mg/kg, s.c., a single time) reduces blood glucose, promotes insulin induction, and leads to more pronounced body weight reduction compared to Semaglutide (HY-114118) in db/db mice[2].
Ecnoglutide (1 mg/kg, s.c., rats) shows the T1/2 (h), Tmax (h), Cmax (nM), AUClast (h*nM), MRT (h) values of 11.7, 18 .0, 387.3, 16274.8, 25.4 respectively[2].
| | References | [1] WHO Drug Information, Vol. 35, No. 4, 2021. Geneva: World Health Organization; 2022.
[2] Guo W, et al. Discovery of ecnoglutide - A novel, long-acting, cAMP-biased glucagon-like peptide-1 (GLP-1) analog. Mol Metab. 2023 Sep;75:101762. DOI:10.1016/j.molmet.2023.101762 |
| | Ecnoglutide Preparation Products And Raw materials |
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