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MedChemexpress LLC
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Product Name:KP136
CAS:76239-32-2
Purity:400RMB/1mg Package:>98%
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| Company Name: |
BOC Sciences
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| Tel: |
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| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:KP136
CAS:76239-32-2
Remarks:KP136, an antiallergic agent, remarkably inhibited the passive cutaneous anaphylaxis (PCA) with intravenous and oral dosing. KP-136 is an oral potent inhibitor on PCA, and it acts by blocking the rele
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KP 136 manufacturers
- KP136
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- $293.00 / 1mg
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2025-11-03
- CAS:76239-32-2
- Min. Order:
- Purity: 98.61%
- Supply Ability: 10g
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| Product Name: | KP 136 | | Synonyms: | KP 136;8-(Hexyloxy)-3-(1H-tetrazol-5-yl)-2H-1-benzopyran-2-one;8-(Hexyloxy)-3-(1H-tetrazol-5-yl)coumarin;AL-136;2H-1-Benzopyran-2-one, 8-(hexyloxy)-3-(2H-tetrazol-5-yl)-;KP-136,KP136;8-Hexyloxy-3-(1H-tetrazol-5-yl)-2H-chromen-2-one | | CAS: | 76239-32-2 | | MF: | C16H18N4O3 | | MW: | 314.343 | | EINECS: | | | Product Categories: | | | Mol File: | 76239-32-2.mol |  |
| | KP 136 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO |
| | KP 136 Usage And Synthesis |
| Uses | KP136 (AL136) is an orally effective antiallergic agent. The IC50 is 76.1 μg/mL for histamine release and 63 ug/mL for degranulation[1]. | | in vivo | C4C at 0.2 mg/kg produces an equipotent effect to 1 mg/kg KP136 (KP-136) or 5 mg/kg DSCG. However, C4C is less effective by the oral route because it only produces a maximum inhibition of about 35% even at the high dose of 100 mg/kg, whereas KP136 shows an overt inhibitory effect of about 66% at the oral dose of 2 mg/kg. On the other hand, KP136 (1 mg/kg, i.v.) also remarkably inhibits 5-h homologous PCA, having an activity similar to that of C4C[1]. | | References | [1] Kuriyama K, et al. Antiallergic effects of 4-[2-oxo-3-(1H-tetrazol-5-yl)-2H-chromen-8-yloxy]-bu tyric acid. Jpn J Pharmacol. 1989 Jun;50(2):111-8. DOI:10.1254/jjp.50.111 |
| | KP 136 Preparation Products And Raw materials |
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