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| | L 685818 Basic information |
| Product Name: | L 685818 | | Synonyms: | L 685818;L 685;L685;L-685;15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,11,19-trihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-, (3S,4R,5S,8R,9E,11S,1... | | CAS: | 143839-74-1 | | MF: | C43H69NO13 | | MW: | 808.02 | | EINECS: | | | Product Categories: | | | Mol File: | 143839-74-1.mol |  |
| | L 685818 Chemical Properties |
| Boiling point | 896.7±75.0 °C(Predicted) | | density | 1.22±0.1 g/cm3(Predicted) | | pka | 9.94±0.70(Predicted) |
| | L 685818 Usage And Synthesis |
| Description | L 685818 is the C18-hydroxy, C21-ethyl analog of FK-506; binds to FKBP-12; antagonizes FK-506 and rapamycin. | | Uses | L685818 is a specific immunophilin ligand. L685818 was neuroregenerative and non-neuroprotective in primary brain cultures. L685818 protects dopaminergic neurons from toxic inhibition of MPP+ and 6-OHDA, reduces tyrosine hydroxylase (TH) loss, and promotes neuronal process regeneration. L685818 is also an antifungal reagent for Cryptococcus neoformans[1][2]. | | References | [1] Guo X, et al. Neuroimmunophilin ligands exert neuroregeneration and neuroprotection in midbrain dopaminergic neurons. Eur J Neurosci. 2001 May;13(9):1683-93. DOI:10.1046/j.0953-816x.2001.01542.x
[2] Odom A, et al. The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein. Antimicrob Agents Chemother. 1997 Jan;41(1):156-61. DOI:10.1128/AAC.41.1.156 |
| | L 685818 Preparation Products And Raw materials |
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