2-[4-[[4-Amino-3-(2-amino-5-benzoxazolyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-1-piperidinyl]-N-hydroxy-5-pyrimidinecarboxamide

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2-[4-[[4-Amino-3-(2-amino-5-benzoxazolyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-1-piperidinyl]-N-hydroxy-5-pyrimidinecarboxamide Basic information
Product Name:2-[4-[[4-Amino-3-(2-amino-5-benzoxazolyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-1-piperidinyl]-N-hydroxy-5-pyrimidinecarboxamide
Synonyms:2-[4-[[4-Amino-3-(2-amino-5-benzoxazolyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-1-piperidinyl]-N-hydroxy-5-pyrimidinecarboxamide
CAS:2815286-02-1
MF:C23H23N11O3
MW:501.5
EINECS:
Product Categories:
Mol File:2815286-02-1.mol
2-[4-[[4-Amino-3-(2-amino-5-benzoxazolyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-1-piperidinyl]-N-hydroxy-5-pyrimidinecarboxamide Structure
2-[4-[[4-Amino-3-(2-amino-5-benzoxazolyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-1-piperidinyl]-N-hydroxy-5-pyrimidinecarboxamide Chemical Properties
density 1.78±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
pka8.12±0.10(Predicted)
Safety Information
MSDS Information
2-[4-[[4-Amino-3-(2-amino-5-benzoxazolyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-1-piperidinyl]-N-hydroxy-5-pyrimidinecarboxamide Usage And Synthesis
UsesmTOR/HDAC-IN-1 (Compound 50) is a selective mTOR and HDAC dual inhibitor with IC50 values of 0.49 and 0.91 nM against mTOR and HDAC1, respectively. mTOR/HDAC-IN-1 can be studied as an anti-cancer agent[1].
IC 50mTOR: 0.49 nM (IC50); HDAC1: 0.91 nM (IC50); HDAC6: 86 nM (IC50); HDAC8: 27 nM (IC50)
References[1] Mingming Zhang, et al. Discovery of novel pyrazolopyrimidine derivatives as potent mTOR/HDAC bi-functional inhibitors via pharmacophore-merging strategy. Bioorg Med Chem Lett. 2021 Oct 1;49:128286. DOI:10.1016/j.bmcl.2021.128286
2-[4-[[4-Amino-3-(2-amino-5-benzoxazolyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-1-piperidinyl]-N-hydroxy-5-pyrimidinecarboxamide Preparation Products And Raw materials
Tag:2-[4-[[4-Amino-3-(2-amino-5-benzoxazolyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-1-piperidinyl]-N-hydroxy-5-pyrimidinecarboxamide(2815286-02-1) Related Product Information
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