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| | acanthifolicin Basic information |
| Product Name: | acanthifolicin | | Synonyms: | acanthifolicin;Acanthifolic acid;Spiro[3-oxa-7-thiabicyclo[4.1.0]heptane-2,2′-[2H]pyran]-6′-propanoic acid, tetrahydro-α,3′-dihydroxy-α,6-dimethyl-4-[(1R,2E)-1-methyl-3-[(2R,4′aR,5R,6′S,8′R,8′aS)-octahydro-8′-hydroxy-6′-[(1S,3S)-1-hydroxy-3-[(2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undec-2-yl]butyl]-7′-methylenespiro[furan-2(3H),2′(3′H)-pyrano[3,2-b]pyran]-5-yl]-2-propen-1-yl]-, (αR,1S,2S,3′R,4S,6R,6′S)- | | CAS: | 77739-71-0 | | MF: | C44H68O13S | | MW: | 837.07 | | EINECS: | | | Product Categories: | | | Mol File: | 77739-71-0.mol |  |
| | acanthifolicin Chemical Properties |
| Melting point | 166-167 °C | | Boiling point | 947.4±65.0 °C(predicted) | | density | 1.32±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | | pka | 3.87±0.16(predicted) |
| | acanthifolicin Usage And Synthesis |
| Description | Acanthifolicin is an okadaic acid derivative that has been shown top inhibit protein phosphatase 1 with an IC50= 20 nM (similar to that of okadaic acid at 19 nM). | | Uses | Acanthifolicin, a derivative of Okadaic acid (HY-N6785), is a protein phosphatase inhibitor. Acanthifolicin inhibits protein phosphatase-1 (PP1) and PP2 with IC50 values of 20 nM and 1 nM, respectively[1]. | | Definition | ChEBI: Acanthifolicin is a ketal. | | References | [1] Holmes CF, et al. Inhibition of protein phosphatases-1 and -2A with acanthifolicin. Comparison with diarrhetic shellfish toxins and identification of a region on okadaic acid important for phosphatase inhibition. FEBS Lett. 1990 Sep 17;270(1-2):216-8. DOI:10.1016/0014-5793(90)81271-o |
| | acanthifolicin Preparation Products And Raw materials |
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