Pentanamide, 5-[(4,5-dihydro-4-oxo-3H-pyrimido[5,4-b]indol-2-yl)thio]-N-hydroxy-

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Pentanamide, 5-[(4,5-dihydro-4-oxo-3H-pyrimido[5,4-b]indol-2-yl)thio]-N-hydroxy- Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:Topo II/HDAC-IN-1
CAS:2922269-18-7
Package:10mg;50mg
Pentanamide, 5-[(4,5-dihydro-4-oxo-3H-pyrimido[5,4-b]indol-2-yl)thio]-N-hydroxy- Basic information
Product Name:Pentanamide, 5-[(4,5-dihydro-4-oxo-3H-pyrimido[5,4-b]indol-2-yl)thio]-N-hydroxy-
Synonyms:Pentanamide, 5-[(4,5-dihydro-4-oxo-3H-pyrimido[5,4-b]indol-2-yl)thio]-N-hydroxy-;Topo II/HDAC-IN-1
CAS:2922269-18-7
MF:C15H16N4O3S
MW:332.38
EINECS:
Product Categories:
Mol File:2922269-18-7.mol
Pentanamide, 5-[(4,5-dihydro-4-oxo-3H-pyrimido[5,4-b]indol-2-yl)thio]-N-hydroxy- Structure
Pentanamide, 5-[(4,5-dihydro-4-oxo-3H-pyrimido[5,4-b]indol-2-yl)thio]-N-hydroxy- Chemical Properties
density 1.55±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
pka9.41±0.20(Predicted)
Safety Information
MSDS Information
Pentanamide, 5-[(4,5-dihydro-4-oxo-3H-pyrimido[5,4-b]indol-2-yl)thio]-N-hydroxy- Usage And Synthesis
UsesTopo II/HDAC-IN-1 (7d) exhibits excellent dual inhibitory activities against Topo II and HDAC. Topo II/HDAC-IN-1 (8d) induces apoptosis[1].
References[1] Mengmiao Zhao, et al. Design, synthesis and biological evaluation of dual Topo II/HDAC inhibitors bearing pyrimido[5,4-b]indole and pyrazolo[3,4-d]pyrimidine motifs. Eur J Med Chem.2023 Apr 5;252:115303. DOI:10.1016/j.ejmech.2023.115303
Pentanamide, 5-[(4,5-dihydro-4-oxo-3H-pyrimido[5,4-b]indol-2-yl)thio]-N-hydroxy- Preparation Products And Raw materials
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