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| | 4-Hydroxy-6-aminopyrimidine Basic information |
| | 4-Hydroxy-6-aminopyrimidine Chemical Properties |
| Melting point | 262-264°C | | Boiling point | 227.5±43.0 °C(Predicted) | | density | 1.55±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | DMSO | | form | Solid | | pka | 10.04±0.40(Predicted) | | color | White | | BRN | 112429 | | InChI | InChI=1S/C4H5N3O/c5-3-1-4(8)7-2-6-3/h1-2H,(H3,5,6,7,8) | | InChIKey | HFMLLTVIMFEQRE-UHFFFAOYSA-N | | SMILES | C1=NC(N)=CC(=O)N1 | | CAS DataBase Reference | 1193-22-2(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38-41 | | Safety Statements | 26-36-39 | | WGK Germany | WGK 3 | | HazardClass | IRRITANT | | HS Code | 2933599590 | | Storage Class | 13 - Non Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Provider | Language |
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ALFA
| English |
| | 4-Hydroxy-6-aminopyrimidine Usage And Synthesis |
| Chemical Properties | White Solid | | Synthesis | Step 2: 2-mercapto-4-amino-6-hydroxypyridine (mass ratio 1:15) was added to 25% ammonia, followed by the addition of activated nickel and titanium dioxide, wherein the molar ratio of 2-mercapto-4-amino-6-hydroxypyridine, activated nickel and titanium dioxide was 1:4:1.5. The mixture was heated to 90°C and the reaction was carried out at reflux for 5 hours. Upon completion of the reaction, the activated nickel and titanium dioxide were removed by thermal filtration. The filtrate was cooled to room temperature and the solid product was precipitated. The solid was washed with 30 mL of water and dried at 40 °C to afford 4-amino-6-hydroxypyrimidine in 98.4% yield. | | References | [1] Patent: CN105218554, 2016, A. Location in patent: Paragraph 0023
[2] Journal of Medicinal Chemistry, 2002, vol. 45, # 9, p. 1918 - 1929
[3] Patent: EP1406911, 2016, B1. Location in patent: Paragraph 00382; 00383 |
| | 4-Hydroxy-6-aminopyrimidine Preparation Products And Raw materials |
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