vasotocin, (beta-mercapto-beta,beta-cyclopentamethylenepropionic acid)-O-methyl-Tyr(2)-Thr(4)-Orn(8)-Tyr(9)-NH2 manufacturers
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| | vasotocin, (beta-mercapto-beta,beta-cyclopentamethylenepropionic acid)-O-methyl-Tyr(2)-Thr(4)-Orn(8)-Tyr(9)-NH2 Basic information |
| Product Name: | vasotocin, (beta-mercapto-beta,beta-cyclopentamethylenepropionic acid)-O-methyl-Tyr(2)-Thr(4)-Orn(8)-Tyr(9)-NH2 | | Synonyms: | vasotocin, (beta-mercapto-beta,beta-cyclopentamethylenepropionic acid)-O-methyl-Tyr(2)-Thr(4)-Orn(8)-Tyr(9)-NH2;(2S)-N-[(2R)-1-[(2S)-2-[[(2S)-5-amino-1-[[(2S)-1-amino-3-(4-methoxyphenyl)-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-3-sulfanylidenepropan-2-yl]-2-[[(2S,3R)-3-hydroxy-2-[[(2S,3S)-2-[[(2S)-3-(4-hydroxyphenyl)-2-[[2-(1-sulfanylcyclohexyl)acetyl]amino]propanoyl]amino]-3-methylpentanoyl]amino]butanoyl]amino]butanediamide;b-Mercapto-b,b-cyclopentaMethylene-propionyl-Tyr(Me)-Ile-Thr-Asn-Cys-Pro-Orn-Tyr-NH2;OVTA;L-Tyrosinamide, N-[2-(1-mercaptocyclohexyl)acetyl]-O-methyl-L-tyrosyl-L-isoleucyl-L-threonyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-ornithyl-, cyclic (1→5)-disulfide;(2S)-N-[(2R)-1-[(2S)-2-[[(2S)-5-amino-1-[[(2S)-1-amino-3-(4-methoxyphenyl)-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-3-sulfanylidenepropan-2-yl]-2-[[(2S,3R)-3-hydroxy-2-[[(2S,3S)-2-[[(2S)-3-(4-hydroxyphenyl)-2-[[2-(1-sulfan;Ota-vasotocin;(d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH2?)-Vasotocin | | CAS: | 114056-26-7 | | MF: | C54H79N11O13S2 | | MW: | 1154.4 | | EINECS: | | | Product Categories: | | | Mol File: | 114056-26-7.mol |  |
| | vasotocin, (beta-mercapto-beta,beta-cyclopentamethylenepropionic acid)-O-methyl-Tyr(2)-Thr(4)-Orn(8)-Tyr(9)-NH2 Chemical Properties |
| Sequence | Mpa(Cy)-Tyr(Me)-Ile-Thr-Asn-Cys-Pro-{Orn}-Tyr-NH2 (disulfide bridge:Mpa1-Cys6) |
| | vasotocin, (beta-mercapto-beta,beta-cyclopentamethylenepropionic acid)-O-methyl-Tyr(2)-Thr(4)-Orn(8)-Tyr(9)-NH2 Usage And Synthesis |
| Description | Ota-vasotocin is a ligand used in quantitative receptor autoradiography for oxytocin receptors. | | Uses | (d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin is an oxytocin antagonist and can be used for the research of sexual behavior[1]. | | in vivo | (d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin (50-1000 ng; Intra-MPOA; 1 μL) inhibits certain aspects of male sexual behavior in rats[1].
(d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin (100 ng; i.c.v.; 1 μL) effectively suppresses hypoalgesia following copulatory behavior in male rats[2]. | Animal Model: | Adult Long–Evans/Blue-Spruce rats[1] | | Dosage: | 50 ng, 200 ng, and 1 μg | | Administration: | Intra-MPOA (medial preoptic area) injection, 1 μL | | Result: | Significantly increased intromission latency and anogenital investigation at 1 μg dose. Significantly decreased intromission ratio (2) at all doses. |
| Animal Model: | Adult male and female Long-Evans rats (8 weeks old, 220–260 g BW)[2] | | Dosage: | 100 ng | | Administration: | Intracerebroventricular injection, 1 μL | | Result: | Was effective in reducing pain threshold heightened by copulatory behavior. |
| | References | [1] Gil M, et al. Oxytocin in the medial preoptic area facilitates male sexual behavior in the rat. Horm Behav. 2011 Apr;59(4):435-43. DOI:10.1016/j.yhbeh.2010.12.012
[2] Futagami H, et al. Oxytocin mediates copulation-induced hypoalgesia of male rats. Neurosci Lett. 2016 Apr 8;618:122-126. DOI:10.1016/j.neulet.2016.03.007 |
| | vasotocin, (beta-mercapto-beta,beta-cyclopentamethylenepropionic acid)-O-methyl-Tyr(2)-Thr(4)-Orn(8)-Tyr(9)-NH2 Preparation Products And Raw materials |
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