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| | 2-phenyl-1,2-benzisothiazol-3-(2H)-one Basic information |
| Product Name: | 2-phenyl-1,2-benzisothiazol-3-(2H)-one | | Synonyms: | 2-phenyl-1,2-benzisothiazol-3-(2H)-one;2-phenylbenzo[d]isothiazol-3(2H)-one;2-phenyl-1,2-benzothiazol-3-one;2-Phenyl-1-thia-2-azaindan-3-one;2-Phenyl-2,3-dihydro-1,2-benzoisothiazole-3-one;PZ-25;RP-62373;1,2-Benzisothiazol-3(2H)-one, 2-phenyl- | | CAS: | 2527-03-9 | | MF: | C13H9NOS | | MW: | 227.28 | | EINECS: | | | Product Categories: | | | Mol File: | 2527-03-9.mol |  |
| | 2-phenyl-1,2-benzisothiazol-3-(2H)-one Chemical Properties |
| Melting point | 139-140 °C(Solv: ethanol (64-17-5)) | | Boiling point | 388.9±25.0 °C(Predicted) | | density | 1.338±0.06 g/cm3(Predicted) | | pka | -0.55±0.20(Predicted) |
| | 2-phenyl-1,2-benzisothiazol-3-(2H)-one Usage And Synthesis |
| Uses | Ebsulfur is a benzisothiazolone cytocidal inhibitor targeting the trypanothione reductase (TryR) of Trypanosoma brucei, with IC50 values of 61-293 nM for Trypanosoma brucei. Ebsulfur can be used for the research of African trypanosomiasis[1]. | | References | [1] Lu J, et al. Ebsulfur is a benzisothiazolone cytocidal inhibitor targeting the trypanothione reductase of Trypanosoma brucei. J Biol Chem. 2013 Sep 20;288(38):27456-27468. DOI:10.1074/jbc.M113.495101 |
| | 2-phenyl-1,2-benzisothiazol-3-(2H)-one Preparation Products And Raw materials |
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