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MedChemexpress LLC
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021-58955995 |
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| Products Intro: |
Product Name:HSR6071
CAS:111374-21-1
Purity:200RMB/1mg Package:>98%
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HSR 6071 manufacturers
- HSR6071
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- $247.00 / 5mg
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2026-04-22
- CAS:111374-21-1
- Min. Order:
- Purity: 99.59%
- Supply Ability: 10g
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| | HSR 6071 Basic information |
| Product Name: | HSR 6071 | | Synonyms: | HSR 6071;6-(1-Pyrrolidinyl)-N-(1H-tetrazol-5-yl)pyrazine-2-carboxamide;N-(1H-Tetrazol-5-yl)-6-(1-pyrrolidinyl)pyrazine-2-carboxamide;2-Pyrazinecarboxamide, 6-(1-pyrrolidinyl)-N-2H-tetrazol-5-yl-;HSR6071,HSR-6071 | | CAS: | 111374-21-1 | | MF: | C10H12N8O | | MW: | 260.26 | | EINECS: | | | Product Categories: | | | Mol File: | 111374-21-1.mol |  |
| | HSR 6071 Chemical Properties |
| Melting point | 288-294 °C (decomp)(Solv: dimethyl sulfoxide (67-68-5)) | | density | 1.555±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 2.61±0.10(Predicted) | | color | Light yellow to yellow |
| | HSR 6071 Usage And Synthesis |
| Uses | HSR6071, a pyrazinecarboxamide derivative, is an orally active and potent antiallergic agent. HSR6071 potently inhibits the experimental asthma in rat models[1][2]. | | in vivo | The experimental asthma caused by IgE antibody in rats is inhibited by HSR-6071 (0.01-0.1 mg/kg; i.v.) in a dose-dependent manner. The bronchoconstriction mediated by IgE or IgG antibody in guinea-pigs is also prevented by HSR-6071 (0.3, 1,3 mg/kg; i.v.). HSR-6071 inhibits cyclic AMP phosphodiesterase activity and produces relaxation of the guinea-pig isolated trachea[1].
HSR-6071 inhibits the IgE-mediated histamine release with an IC50 of 0.46 nM. HSR-6071 is effective not only by i.v. but also by p.o. administration on the IgE mediated PCA in rats. The most potent inhibition with HSR-6071 is observed when it is given p.o. 5 min before the antigen challenge, indicating the rapid absorption of HSR-6071 through the gastrointestinal tract[2].
| | References | [1] Makino E, et al. Inhibitory effect of HSR-6071, a new anti-allergic agent, on experimental asthma in rats and guinea-pigs. J Pharm Pharmacol. 1990 Apr;42(4):236-41. DOI:10.1111/j.2042-7158.1990.tb05399.x
[2] Makino E, et al. Potent inhibitory activity of HSR-6071, a new antiallergic agent, on passive cutaneousanaphylaxis (PCA). Jpn J Pharmacol. 1990 Jan;52(1):87-94. DOI:10.1254/jjp.52.87 |
| | HSR 6071 Preparation Products And Raw materials |
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