5-[1-(4-Fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-4-pyrimidinamine

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5-[1-(4-Fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-4-pyrimidinamine Suppliers list
Company Name: Shanghai Beckham Medical Technology Co., Ltd  
Tel: 13816613772
Email: huahero21@sina.com
Products Intro: Product Name:BMS-737
CAS:1356053-63-8
Purity:98% HPLC Package:1g
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:BMS-737
CAS:1356053-63-8
Package:50mg;10mg
5-[1-(4-Fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-4-pyrimidinamine Basic information
Product Name:5-[1-(4-Fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-4-pyrimidinamine
Synonyms:5-[1-(4-Fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-4-pyrimidinamine;BMS-737
CAS:1356053-63-8
MF:C16H11FN6
MW:306.3
EINECS:
Product Categories:
Mol File:1356053-63-8.mol
5-[1-(4-Fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-4-pyrimidinamine Structure
5-[1-(4-Fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-4-pyrimidinamine Chemical Properties
Boiling point 487.3±45.0 °C(Predicted)
density 1.49±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
pka3.76±0.10(Predicted)
Safety Information
MSDS Information
5-[1-(4-Fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-4-pyrimidinamine Usage And Synthesis
UsesBMS-737 (compound 33) is a non-steroidal, reversible small molecule inhibitor. BMS-737 exhibits 11-fold selectivity for CYP17 lyase over CYP17 hydroxylase. BMS-737 is designed to inhibit castration-resistant prostate cancer (CRPC) and significantly reduces testosterone levels without significant effects on orrodermal hormone and glucocorticoid levels[1].
References[1] Padmakar Darne C, et al. The discovery of BMS-737 as a potent, CYP17 lyase-selective inhibitor for the treatment of castration-resistant prostate cancer. Bioorg Med Chem Lett. 2022 Nov 1;75:128951. DOI:10.1016/j.bmcl.2022.128951
5-[1-(4-Fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-4-pyrimidinamine Preparation Products And Raw materials
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