HNPMI manufacturers
- HNPMI
-
- $34.00
-
2026-07-27
- CAS:1980848-48-3
- Purity: 99.70%
- Supply Ability: 10g
|
| Product Name: | HNPMI | | Synonyms: | HNPMI;Phenol, 2-[(2,3-dihydro-1H-indol-1-yl)(4-methylphenyl)methyl]-4-nitro- | | CAS: | 1980848-48-3 | | MF: | C22H20N2O3 | | MW: | 360.41 | | EINECS: | | | Product Categories: | | | Mol File: | 1980848-48-3.mol |  |
| | HNPMI Chemical Properties |
| Boiling point | 577.430±50.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.295±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 6.388±0.30(predicted) | | form | Solid | | color | Light yellow to yellow |
| | HNPMI Usage And Synthesis |
| Uses | HNPMI is an inhibitor of EGFR and has cytotoxic effects on tumor cells. HNPMI can downregulate the protein levels of osteopontin, survivin and cathepsin S, leading to apoptosis. HNPMI also regulates BCL-2/BAX and p53 in CRC cell lines to inhibit tumorigenesis[1]. | | References | [1] Kandhavelu J, et al. A novel EGFR inhibitor, HNPMI, regulates apoptosis and oncogenesis by modulating BCL-2/BAX and p53 in colon cancer. Br J Pharmacol. 2024 Jan;181(1):107-124. DOI:10.1111/bph.16141 |
| | HNPMI Preparation Products And Raw materials |
|