ALK/EGFR-IN-2 manufacturers
- ALK/EGFR-IN-2
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- $2180.00
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2026-05-11
- CAS:2730432-75-2
- Purity:
- Supply Ability: 10g
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| | ALK/EGFR-IN-2 Basic information |
| Product Name: | ALK/EGFR-IN-2 | | Synonyms: | ALK/EGFR-IN-2;2-Propenamide, N-[5-[[5-chloro-4-[[2-[(R)-ethylsulfinyl]phenyl]amino]-2-pyrimidinyl]amino]-2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxyphenyl]- | | CAS: | 2730432-75-2 | | MF: | C27H34ClN7O3S | | MW: | 572.12 | | EINECS: | | | Product Categories: | | | Mol File: | 2730432-75-2.mol |  |
| | ALK/EGFR-IN-2 Chemical Properties |
| density | 1.343±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 12.653±0.70(predicted) |
| | ALK/EGFR-IN-2 Usage And Synthesis |
| Uses | ALK/EGFR-IN-2 is a potent dual inhibitor of ALK and EGFR. ALK/EGFR-IN-2 induces apoptosis and G0/G1 cell cycle arrest in cancer cells. ALK/EGFR-IN-2 significantly inhibits the cell proliferation of H1975, PC9, and Baf3-EML4-ALK cancer cell lines with IC50s of 0.0034, 0.0065, and 0.0018 μM, respectively[1]. | | References | [1] An B, et al. Discovery of potent and effective inhibitors containing sulfoxide structures targeting EML4-ALK rearrangement and EGFR mutant non-small cell lung cancer. Bioorg Chem. 2023 Sep;138:106653. DOI:10.1016/j.bioorg.2023.106653 |
| | ALK/EGFR-IN-2 Preparation Products And Raw materials |
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