1-Methyl-2-oxo-4-[4-[4-(trifluoromethoxy)phenoxy]-1-piperidyl]-1,2-dihydroquinoline-3-carboxamide

Company Name:	Shanghai Beckham Medical Technology Co., Ltd
Tel:	13816613772
Email:	huahero21@sina.com

1-Methyl-2-oxo-4-[4-[4-(trifluoromethoxy)phenoxy]-1-piperidyl]-1,2-dihydroquinoline-3-carboxamide manufacturers

1-Methyl-2-oxo-4-[4-[4-(trifluoromethoxy)phenoxy]-1-piperidyl]-1,2-dihydroquinoline-3-carboxamide Basic information

Product Name:	1-Methyl-2-oxo-4-[4-[4-(trifluoromethoxy)phenoxy]-1-piperidyl]-1,2-dihydroquinoline-3-carboxamide
Synonyms:	1-Methyl-2-oxo-4-[4-[4-(trifluoromethoxy)phenoxy]-1-piperidyl]-1,2-dihydroquinoline-3-carboxamide;DGKα-IN-2;3-Quinolinecarboxamide, 1,2-dihydro-1-methyl-2-oxo-4-[4-[4-(trifluoromethoxy)phenoxy]-1-piperidinyl]-
CAS:	2648556-92-5
MF:	C23H22F3N3O4
MW:	461.43
EINECS:
Product Categories:
Mol File:	2648556-92-5.mol

1-Methyl-2-oxo-4-[4-[4-(trifluoromethoxy)phenoxy]-1-piperidyl]-1,2-dihydroquinoline-3-carboxamide Chemical Properties

Boiling point	576.187±50.00 °C(Press: 760.00 Torr)(predicted)
density	1.388±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
form	Solid
pka	14.716±0.20(predicted)
color	White to off-white

Safety Information

MSDS Information

1-Methyl-2-oxo-4-[4-[4-(trifluoromethoxy)phenoxy]-1-piperidyl]-1,2-dihydroquinoline-3-carboxamide Usage And Synthesis

Uses	DGKα-IN-2 (example 48) is a DGKα inhibitor with the IC50 of 0.9 nM, extracted from patent WO2021105115. DGKα-IN-2 significantly enhances the anti-tumor effect of anti-PD-1 by increasing the proliferation and function of T cells. DGKα-IN-2 has the potential for cancer and immunology study.
References	[1] Schmees, Norbert, et al. Preparation of substituted aminoquinolones as DGKα inhibitors for immune activation. WO2021105115.

1-Methyl-2-oxo-4-[4-[4-(trifluoromethoxy)phenoxy]-1-piperidyl]-1,2-dihydroquinoline-3-carboxamide Preparation Products And Raw materials

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