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| | PROTAC BRD4 Degrader-22 Basic information |
| Product Name: | PROTAC BRD4 Degrader-22 | | Synonyms: | PROTAC BRD4 Degrader-22;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-[[1-[4-[[(2,6-dioxo-3-piperidinyl)amino]carbonyl]-3-methoxyphenyl]-4-piperidinyl]methyl]-2,3,9-trimethyl-, (6S)- | | CAS: | 3032850-37-3 | | MF: | C38H41ClN8O5S | | MW: | 757.3 | | EINECS: | | | Product Categories: | | | Mol File: | 3032850-37-3.mol |  |
| | PROTAC BRD4 Degrader-22 Chemical Properties |
| density | 1.489±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
| | PROTAC BRD4 Degrader-22 Usage And Synthesis |
| Uses | PROTAC BRD4 Degrader-22 (Compd 44h) is a PROTAC-based BRD4 degrader, with a pDC50 (MOLT4, 24 h) of 9.2[1]. | | References | [1] Christian Steinebach, et al. Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs. J Med Chem. 2023 Oct 30. DOI:10.1021/acs.jmedchem.3c00851 |
| | PROTAC BRD4 Degrader-22 Preparation Products And Raw materials |
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