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| | 2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine Basic information |
| Product Name: | 2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine | | Synonyms: | 2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine;2,6-DICHLORO-4,8-DI-1-PIPERIDINYLPYRIMIDO[5,4-D]PYRIMIDINEDIPYRIDAMOLE;Einecs 230-437-4;PyriMido[5,4-d]pyriMidine,2,6-dichloro-4,8-di-1-piperidinyl-;2,6-dichloro-4,8-dipiperidinyl-pyrimido[5,4-d]pyrimidine;2,6-Dichloro-4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidine;2,6-dichloro-4,8-bis(1-piperidinyl)pyrimido[5,4-d]pyrimidine;Dipyridamole Impurity 7（Dipyridamole EP Impurity G） | | CAS: | 7139-02-8 | | MF: | C16H20Cl2N6 | | MW: | 367.28 | | EINECS: | 230-437-4 | | Product Categories: | Bases & Related Reagents;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals | | Mol File: | 7139-02-8.mol | ![2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine Structure](CAS/GIF/7139-02-8.gif) |
| | 2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine Chemical Properties |
| Melting point | 249-251℃ | | Boiling point | 504.1±50.0 °C(Predicted) | | density | 1.386±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | Chloroform (Slightly) | | form | Solid | | pka | 2.00±0.30(Predicted) | | color | Pale Yellow to Light Yellow | | InChI | InChI=1S/C16H20Cl2N6/c17-15-20-12-11(13(21-15)23-7-3-1-4-8-23)19-16(18)22-14(12)24-9-5-2-6-10-24/h1-10H2 | | InChIKey | PCVJQTVUJJJSRQ-UHFFFAOYSA-N | | SMILES | C1(Cl)=NC(N2CCCCC2)=C2N=C(Cl)N=C(N3CCCCC3)C2=N1 | | LogP | 2 |
| WGK Germany | WGK 3 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects |
| | 2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine Usage And Synthesis |
| Chemical Properties | Beige Solid | | Uses | An antitumor nucleoside pyrimido pyrimidine. | | Synthesis | General procedure for the synthesis of 2,6-dichloro-4,8-dipiperidinosubstituted pyrimido[5,4-d]pyrimidines from hexahydropyridine and perchloropyrimido[5,4-d]pyrimidines: perchloropyrimido[5,4-d]pyrimidines (13.1 g, 48.9 mmol), piperidines, CuI (0.28 g, 1.5 mmol) and Cs2CO3 (16.0 g, 48.9 mmol) were added to a 250mL two-necked flask. 100 mL of nitrobenzene was added as reaction solvent and the reaction was carried out at 180°C for 16 h under nitrogen protection. After completion of the reaction, the nitrobenzene solvent was removed by distillation under reduced pressure. Purification by column chromatography using a solvent mixture of petroleum ether (PE) and dichloromethane (DCM) (6:1, v/v) gave 17.0 g of solid product in 95.0% yield and 99% selectivity. | | References | [1] Patent: CN106946887, 2017, A. Location in patent: Paragraph 0035; 0036; 0037
[2] Journal of Medicinal Chemistry, 2004, vol. 47, # 20, p. 4905 - 4922
[3] Medicinal Chemistry Research, 1996, vol. 6, # 1, p. 61 - 67
[4] Journal of Medicinal Chemistry, 2007, vol. 50, # 16, p. 3906 - 3920
[5] Patent: CN108069972, 2018, A. Location in patent: Paragraph 0005; 0017 |
| | 2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine Preparation Products And Raw materials |
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