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| | 4-(2-Chloroethyl)morpholine hydrochloride Basic information |
| | 4-(2-Chloroethyl)morpholine hydrochloride Chemical Properties |
| Melting point | 180-185 °C (dec.)(lit.) | | storage temp. | Store below +30°C. | | solubility | Chloroform (Slightly, Heated), Methanol (Slightly), Water (Slightly) | | form | Hygroscopic Crystalline Powder | | color | White to beige | | PH | 4.5-5 (10g/l, H2O, 20℃) | | Water Solubility | soluble | | Sensitive | Hygroscopic | | BRN | 3684083 | | InChI | InChI=1S/C6H12ClNO.ClH/c7-1-2-8-3-5-9-6-4-8;/h1-6H2;1H | | InChIKey | NBJHDLKSWUDGJG-UHFFFAOYSA-N | | SMILES | C1OCCN(CCCl)C1.[H]Cl | | CAS DataBase Reference | 3647-69-6(CAS DataBase Reference) | | EPA Substance Registry System | Morpholine, 4-(2-chloroethyl)-, hydrochloride (3647-69-6) |
| Hazard Codes | T | | Risk Statements | 21-25-34-43-52/53 | | Safety Statements | 26-36/37/39-45-61 | | RIDADR | UN 2923 8/PG 3 | | WGK Germany | 2 | | RTECS | QE0260000 | | Autoignition Temperature | 365 °C | | TSCA | TSCA listed | | HazardClass | 8 | | PackingGroup | III | | HS Code | 29349990 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral
Acute Tox. 4 Dermal
Aquatic Chronic 3
Eye Dam. 1
Skin Corr. 1B
Skin Sens. 1 | | Toxicity | LD50 orally in Rabbit: 96 mg/kg LD50 dermal Rat 1502 mg/kg |
| | 4-(2-Chloroethyl)morpholine hydrochloride Usage And Synthesis |
| Chemical Properties | White to beige crystalline powder | | Uses | 4-(2-Chloroethyl)morpholine is used in the preparation of potential DNA cross-linking antitumor agents as well as synthetic opiate analogues. 4-(2-Chloroethyl)morpholine may possess sickle-cell hemogl
obin aggregation inhibiting-activity. | | Uses | 4-(2-Chloroethyl)morpholine hydrochloride (MOC) is used as intermediate for the synthesis of pharmaceuticals (e.g. floredil, morinamide, nimorazole and pholcodine). It is also used as Agrochemical Intermediates, dyestuff Intermediates. | | Safety Profile | Experimental
reproductive effects. Mutation data
reported. When heated to decomposition it
emits very toxic fumes of Cland NOx. | | Synthesis | General procedure for the synthesis of N-(2-chloroethyl)morpholine hydrochloride from morpholine and 2-chloroethanol: 5.0 mL of morpholine (57.5 mmol) and 4.6 mL of 2-chloroethanol (69.0 mmol) were added to 40 mL of toluene, and heated and refluxed for 2 hours. Upon completion of the reaction, the reaction solution was cooled to room temperature and then 8.4 mL (114 mmol) of thionyl chloride was added slowly dropwise under ice bath conditions. After the dropwise addition, the reaction was continued in the ice bath for 20 min, after which the ice bath was removed and the reaction mixture was allowed to stir for 6 h at room temperature. At the end of the reaction, toluene and unreacted thionyl chloride were removed by distillation under reduced pressure. The resulting residue was recrystallized from ethanol to give 7.9 g of N-(2-chloroethyl)morpholine hydrochloride. | | References | [1] Patent: US2013/85140, 2013, A1. Location in patent: Paragraph 0074; 0075
[2] Patent: CN104710394, 2017, B. Location in patent: Paragraph 0039-0041 |
| | 4-(2-Chloroethyl)morpholine hydrochloride Preparation Products And Raw materials |
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