- 1-Formyl-β-carboline
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2020-01-13
- CAS:20127-63-3
- Min. Order: 1g
- Purity: 98%min
- Supply Ability: 1kg-100kg
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| | 1-Formyl-β-carboline Basic information |
| Product Name: | 1-Formyl-β-carboline | | Synonyms: | 1-Formyl-β-carboline;NSC 149850;9H-Pyrido[3,4-b]indole-1-carboxaldehyde;beta-Carboline-1-carbaldehyde;β-Carboline-1-carbaldehyde;Kumujian C;9H-Beta-carboline-1-carboxaldehyde;9H-pyrido[3,4-b]indole-1-carbaldehyde | | CAS: | 20127-63-3 | | MF: | C12H8N2O | | MW: | 196.2 | | EINECS: | | | Product Categories: | | | Mol File: | 20127-63-3.mol |  |
| | 1-Formyl-β-carboline Chemical Properties |
| Melting point | 198-200 °C | | Boiling point | 440.8±25.0 °C(Predicted) | | density | 1.392 | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 14.21±0.40(Predicted) | | form | Solid |
| | 1-Formyl-β-carboline Usage And Synthesis |
| Occurrence | A further alkaloid isolated from the heartwood of Picrasma quassinoides. Like the preceding alkaloid it also inhibits the growth of
certain Staphylococcus aureus strains. | | Uses | 1-Formyl-beta-carboline is an alkaloid with inhibitory activity against Newcastle disease virus (NDV). 1-Formyl-beta-carboline can effectively inhibit different genotypes of NDV with IC50 values within 10 μM, and its inhibition rate is more than 90% at a concentration of 20 μM. 1-Formyl-beta-carboline mainly exerts its effects by inhibiting the adsorption and entry processes in the NDV life cycle. 1-Formyl-beta-carboline has been identified as a novel HN inhibitor that can directly interact with the NDV HN protein and affect the adsorption of NDV. 1-Formyl-beta-carboline also inhibits the entry of NDV by inhibiting the PI3K/Akt signaling pathway rather than the ERK pathway[1]. | | Synthesis Reference(s) | Tetrahedron, 50, p. 12329, 1994 DOI: 10.1016/S0040-4020(01)89542-9 | | References | [1] 1-Formyl- β-carboline Derivatives Block Newcastle Disease Virus Proliferation through Suppressing Viral Adsorption and Entry Processes DOI:10.3390/biom11111687 |
| | 1-Formyl-β-carboline Preparation Products And Raw materials |
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