CYP4A11/CYP4F2-IN-2

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CYP4A11/CYP4F2-IN-2 Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
CYP4A11/CYP4F2-IN-2 Basic information
Product Name:CYP4A11/CYP4F2-IN-2
Synonyms:Propanoic acid, 2-methyl-2-[[7-[[6-(1H-pyrazol-3-yl)-3-pyridinyl]oxy]heptyl]oxy]-
CAS:2280834-99-1
MF:
MW:361.44
EINECS:
Product Categories:
Mol File:2280834-99-1.mol
CYP4A11/CYP4F2-IN-2 Structure
CYP4A11/CYP4F2-IN-2 Chemical Properties
Boiling point 610.164±55.00 °C(Press: 760.00 Torr)(predicted)
density 1.167±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka3.798±0.10(predicted)
Safety Information
MSDS Information
CYP4A11/CYP4F2-IN-2 Usage And Synthesis
UsesCYP4A11/CYP4F2-IN-2 (compound 15) is an orally available inhibitor of CYP4A11/4F2 with IC50s of 120 nM and 220 nM, respectively. CYP4A11/CYP4F2-IN-2 inhibits 20-HETE production in rat kidney and has potential inhibitory effects on diabetic nephropathy and autosomal dominant polycystic kidney disease[1].
References[1] Kawamura M et al. Introduction of a carboxylic acid group into pyrazolylpyridine derivatives increased selectivity for inhibition of the 20-HETE synthase CYP4A11/4F2[J]. Bioorganic & Medicinal Chemistry, 2023: 117505.
CYP4A11/CYP4F2-IN-2 Preparation Products And Raw materials
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