H-D-Phe-Pip-Arg-pNA acetate manufacturers
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| | H-D-Phe-Pip-Arg-pNA acetate Basic information |
| Product Name: | H-D-Phe-Pip-Arg-pNA acetate | | Synonyms: | D-PHE-PIP-ARG-PNA;D-PHE-L-PIPECOLYL-ARG P-NITROANILIDE*TRI ACETATE;D-Phe-Pip-Arg-pNA (Pippipecolyl);H-D-Phe-Pip-Arg-pNA · 2 acetate, H-D-Phe-L-pipecolyl-Arg-pNA · 2 acetate;D-Phe-L-pipecolyl-Arg-p-nitroanilide dihydrochloride;S-2765,Chromogenic Substrate for Fxa;S-2238(Thrombin Substrate);Chromogenix S-2765 | | CAS: | 115388-96-0 | | MF: | C29H40N8O7 | | MW: | 612.69 | | EINECS: | | | Product Categories: | | | Mol File: | 115388-96-0.mol |  |
| | H-D-Phe-Pip-Arg-pNA acetate Chemical Properties |
| storage temp. | −20°C | | form | Solid | | color | White to yellow | | InChIKey | YVHLNJUMPNYROS-IAYLHCNXNA-N | | SMILES | C(=O)(O)C.C([C@@H]1CCCCN1C(=O)[C@H](N)CC1C=CC=CC=1)(=O)N[C@@H](CCCNC(N)=N)C(=O)NC1C=CC(N(=O)=O)=CC=1 |&1:5,13,24,r| |
| | H-D-Phe-Pip-Arg-pNA acetate Usage And Synthesis |
| Uses | H-D-Phe-Pip-Arg-pNA (S-2238) acetate, a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA acetate is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA acetate is sensitive, accurate, and easy to perform[1][2]. | | References | [1] Goodnight SH Jr, et al. Measurement of antithrombin III in normal and pathologic states using chromogenic substrate S-2238. Comparison with immunoelectrophoretic and factor Xa inhibition assays. Am J Clin Pathol. 1980;73(5):639-647. DOI:10.1093/ajcp/73.5.639
[2] Voorthuizen H, Kluft C. Improved assay conditions for automated antithrombin III determinations with the chromogenic substrate S-2238. Thromb Haemost. 1984;52(3):350-353. PMID:6531759 |
| | H-D-Phe-Pip-Arg-pNA acetate Preparation Products And Raw materials |
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