- Hispidol
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- $37.00 / 1mg
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2026-01-16
- CAS:5786-54-9
- Min. Order:
- Purity: 100.00%
- Supply Ability: 10g
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| | 6,4''-DIHYDROXYAURONE Basic information |
| Product Name: | 6,4''-DIHYDROXYAURONE | | Synonyms: | NSC356828;Hispidol, >98%;(Z)-Hispidol;3(2H)-Benzofuranone, 6-hydroxy-2-[(4-hydroxyphenyl)methylene]-, (2Z)-;inhibit,Hispidol,TNF Receptor,Tumor Necrosis Factor Receptor,TNFR,Inhibitor;6,4''-DIHYDROXYAURONE;(2Z)-6-hydroxy-2-[(4-hydroxyphenyl)methylidene]-2,3-dihydro-1-benzofuran-3-one;Hispidol, 10 mM in DMSO | | CAS: | 5786-54-9 | | MF: | C15H10O4 | | MW: | 254.24 | | EINECS: | | | Product Categories: | Aurones | | Mol File: | 5786-54-9.mol |  |
| | 6,4''-DIHYDROXYAURONE Chemical Properties |
| Melting point | 286-288 °C | | Boiling point | 523.8±50.0 °C(Predicted) | | density | 1.489±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 50 mg/ml; DMSO: 25 mg/ml; Ethanol: 10 mg/ml | | pka | 7.59±0.20(Predicted) | | form | A solid | | color | Light yellow to yellow | | Cosmetics Ingredients Functions | ANTIOXIDANT |
| | 6,4''-DIHYDROXYAURONE Usage And Synthesis |
| Uses | Hispidol ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with an IC50 of 0.50 μM. | | Definition | ChEBI: A hydroxyaurone that is aurone substituted by hydroxy groups at positions 6 and 4' respectively. | | in vivo | The oral administration of hispidol suppresses significantly and dose-dependently TNBS-induced rat colitis. Oral administration of hispidol suppresses TNBS-induced colitis in a dose-dependent manner. There is a significant recovery in body weight decrease and colon tissue edematous inflammation. A higher dose (30 mg/kg) of hispidol shows a similar recovery effect to that of 300 mg/kg sulfasalazine. In the colon tissues, TNBS induces a dramatic increase in the level of MPO, a biochemical marker of inflammation, which is suppressed significantly by hispidol in a dose-dependent manner[1]. | | References | [1] Kadayat TM, et al. Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease. Eur J Med Chem. 2017 Sep 8;137:575-597. DOI:10.1016/j.ejmech.2017.06.018 |
| | 6,4''-DIHYDROXYAURONE Preparation Products And Raw materials |
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