| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:SARS-CoV-IN-6
CAS:2244671-47-2
Package:50mg/RMB 13800
|
|
| | SARS-CoV-IN-6 Basic information |
| Product Name: | SARS-CoV-IN-6 | | Synonyms: | SARS-CoV-IN-6;2,4(1H,3H)-Pyrimidinedione, 5-[[[(1R,5S)-1,3,4,5,6,8-hexahydro-8-oxo-3-(phenylmethyl)-1,5-methano-2H-pyrido[1,2-a][1,5]diazocin-9-yl]amino]methyl]-1,3-dimethyl- | | CAS: | 2244671-47-2 | | MF: | C25H29N5O3 | | MW: | 447.53 | | EINECS: | | | Product Categories: | | | Mol File: | 2244671-47-2.mol |  |
| | SARS-CoV-IN-6 Chemical Properties |
| Boiling point | 677.1±65.0 °C(predicted) | | density | 1.35±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | | pka | 8.53±0.40(predicted) |
| | SARS-CoV-IN-6 Usage And Synthesis |
| Uses | SARS-CoV-IN-6 (Compound 17) is an inhibitor of SARS-CoV-1 and SARS-CoV-2 RdRp, with an IC50 value of 7.8 μM against SARS-CoV-2 RdRp. SARS-CoV-IN-6 reduces cytopathic effects in cells infected with SARS-CoV-1 and SARS-CoV-2 replicon-based single-round infectious particles (SRIPs), and inhibits SARS-CoV N protein expression, with EC50 values of 0.12 μM for SARS-CoV-1 replicon-based SRIPs and 1.47 μM for SARS-CoV-2 replicon-based SRIPs[1]. | | References | [1] Chen Y, et al. Assessing the inhibitory effects of some secondary amines, thioureas and 1,3-dimethyluracil conjugates of (-)-cytisine and thermopsine on the RNA-dependent RNA polymerase of SARS-CoV-1 and SARS-CoV-2. Bioorg Med Chem Lett. 2024 Sep 7;113:129950. DOI:10.1016/j.bmcl.2024.129950 |
| | SARS-CoV-IN-6 Preparation Products And Raw materials |
|