PROTAC SMARCA2 degrader-9

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PROTAC SMARCA2 degrader-9 Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
PROTAC SMARCA2 degrader-9 Basic information
Product Name:PROTAC SMARCA2 degrader-9
Synonyms:PROTAC SMARCA2 degrader-9;2,6-Piperidinedione, 3-[5-[3-[4-[2-[3-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-3,8-diazabicyclo[3.2.1]oct-8-yl]-5-pyrimidinyl]-1-piperazinyl]propyl]-2,3-dihydro-3-methyl-2-oxo-1H-benzimidazol-1-yl]-
CAS:2568276-39-9
MF:C40H46N12O4
MW:758.87
EINECS:
Product Categories:
Mol File:2568276-39-9.mol
PROTAC SMARCA2 degrader-9 Structure
PROTAC SMARCA2 degrader-9 Chemical Properties
density 1.387±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka6.274±0.30(predicted)
Safety Information
MSDS Information
PROTAC SMARCA2 degrader-9 Usage And Synthesis
UsesPROTAC SMARCA2 degrader-9 (compound I-285) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment[1].
References[1] Preparation of heterocyclic compounds as SMARCA degraders and uses thereof. World Intellectual Property Organization, WO2020251971 A1 2020-12-17.
PROTAC SMARCA2 degrader-9 Preparation Products And Raw materials
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dTAGV-1 ARV-766 CC-94676 DT2216 Acetamide, N-[7-[(3R)-3-[[5-chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]-1-piperidinyl]heptyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- AU-15330