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| | PNPLA3 degrader-1 Basic information |
| Product Name: | PNPLA3 degrader-1 | | Synonyms: | PNPLA3 degrader-1;1-Piperidinecarboxylic acid, 3,3-difluoro-5-[(5R)-5-methyl-1,1-dioxido-2-isothiazolidinyl]-, 4-chlorophenyl ester, (5R)-;PF-07853578;Uricase, Microorganism | | CAS: | 3036158-98-9 | | MF: | C16H19ClF2N2O4S | | MW: | 408.85 | | EINECS: | | | Product Categories: | | | Mol File: | 3036158-98-9.mol |  |
| | PNPLA3 degrader-1 Chemical Properties |
| Boiling point | 515.020±60.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.490±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | -3.945±0.60(predicted) |
| | PNPLA3 degrader-1 Usage And Synthesis |
| Uses | PF-07853578 (Example 11) is a PNPLA3 degrader with an EC50 of 8 nM. PNPLA3 degrader-1 can be used in the study of cirrhosis and hepatocellular carcinoma[1]. | | References | [1] Christopher William Am Ende, et al. Patatin-like phospholipase domain-containing protein 3 (pnpla3) modifiers. WO, WO2024084360A1. 2024-04-25 |
| | PNPLA3 degrader-1 Preparation Products And Raw materials |
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