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| | H-His-Ser-Leu-Gly-Lys-Leu-Leu-Gly-Arg-Pro-Asp-Lys-Phe-OH Basic information |
| Product Name: | H-His-Ser-Leu-Gly-Lys-Leu-Leu-Gly-Arg-Pro-Asp-Lys-Phe-OH | | Synonyms: | [Leu144, Arg147] - PLP (139 - 151), [L144, R147 - PLP(139 - 151)];SER-HIS-LEU-GLY-LYS-LEU-LEU-GLY-ARG-PRO-ASP-LYS-PHE;(LEU144,ARG147)-MYELIN PROTEOLIPID PROTEIN (139-151);[LEU144, ARG147]-PLP (139-151);L144, R147-PLP(139-151);HIS-SER-LEU-GLY-LYS-LEU-LEU-GLY-ARG-PRO-ASP-LYS-PHE;HSLGKLLGRPDKF;6:PN:WO0053019 SEQID:6 claimed sequence | | CAS: | 188859-65-6 | | MF: | C67H110N20O17 | | MW: | 1467.72 | | EINECS: | | | Product Categories: | peptide | | Mol File: | Mol File |  |
| | H-His-Ser-Leu-Gly-Lys-Leu-Leu-Gly-Arg-Pro-Asp-Lys-Phe-OH Chemical Properties |
| density | 1.42±0.1 g/cm3(Predicted) | | storage temp. | -15°C | | pka | 3.49±0.10(Predicted) | | Sequence | His-Ser-Leu-Gly-Lys-Leu-Leu-Gly-Arg-Pro-Asp-Lys-Phe |
| | H-His-Ser-Leu-Gly-Lys-Leu-Leu-Gly-Arg-Pro-Asp-Lys-Phe-OH Usage And Synthesis |
| Uses | [Leu144,Arg147]-PLP (139-151) is a mutant peptide fragment of myelin proteolipid protein (PLP), with the tryptophan and histidine at positions 144 and 147 respectively replaced by leucine and arginine. [Leu144,Arg147]-PLP (139-151) also serves as a T cell receptor (TCR) antagonist for encephalitogenic Th1 clones, blocking their activation in vitro. Furthermore, [Leu144,Arg147]-PLP (139-151) can inhibit the development of experimental autoimmune encephalomyelitis (EAE)[1]. | | References | [1] Nicholson LB, et al. A T cell receptor antagonist peptide induces T cells that mediate bystander suppression and prevent autoimmune encephalomyelitis induced with multiple myelin antigens. Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9279-84. DOI:10.1073/pnas.94.17.9279 |
| | H-His-Ser-Leu-Gly-Lys-Leu-Leu-Gly-Arg-Pro-Asp-Lys-Phe-OH Preparation Products And Raw materials |
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