- 2-Fluorophenylboronic acid
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- $30.00 / 1KG
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2025-09-25
- CAS:1993-03-9
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
- 2-Fluorophenylboronic acid
-
- $30.00/ Kg
-
2022-10-09
- CAS:1993-03-9
- Min. Order: 100Kg
- Purity: 99.0% up
- Supply Ability: 50 tons per month
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| | 2-Fluorophenylboronic acid Basic information |
| | 2-Fluorophenylboronic acid Chemical Properties |
| Melting point | 101-110 °C (lit.) | | Boiling point | 267.8±42.0 °C(Predicted) | | density | 1.24±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | soluble in Methanol | | form | Crystalline Powder | | pka | 8.32±0.58(Predicted) | | color | White to light yellow | | BRN | 3030413 | | InChI | InChI=1S/C6H6BFO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4,9-10H | | InChIKey | QCSLIRFWJPOENV-UHFFFAOYSA-N | | SMILES | B(C1=CC=CC=C1F)(O)O | | CAS DataBase Reference | 1993-03-9(CAS DataBase Reference) |
| | 2-Fluorophenylboronic acid Usage And Synthesis |
| Chemical Properties | white to light yellow crystalline powder | | Uses | suzuki reaction | | Uses | 2-Fluorophenylboronic Acid, is used in Rh-catalyzed enantioselective addition reactions, and Rhodium and Palladium-catalyzed substitution reactions. It can also be used in the preparation of phenylboronic catechol esters as promising anion receptors for polymer electrolytes. | | Uses | Used for the preparation of biologically active biphenyls and arylboron difluoride Lewis acids. | | Synthesis | The general procedure for the synthesis of 2-fluorophenylboronic acid from o-bromofluorobenzene was as follows: 10.0 g (57.1 mmol) of 1-bromo-2-fluorobenzene and anhydrous tetrahydrofuran were added to a reaction flask and the mixture was subsequently cooled to -70 °C. At -70 °C, 44.2 ml (68.5 mmol) of 1.55 M n-butyllithium solution was slowly added dropwise to the reaction mixture. The temperature was maintained at -70 °C and stirring of the reaction mixture was continued for 1.5 hours. Subsequently, 21.5 g (114.2 mmol) of triisopropyl borate was added dropwise and the reaction temperature was gradually raised to room temperature and stirring was continued for 4 hours. Upon completion of the reaction, aqueous hydrochloric acid was added to the reaction mixture and extracted with dichloromethane. The organic phases were combined and the solvent was removed by distillation under reduced pressure to give the crude product of 2-fluorophenylboronic acid. The crude product was purified by column chromatography (eluent: hexane/acetone) to give 4.8 g (yield: 61%) of pure 2-fluorophenylboronic acid. | | References | [1] Patent: US2012/273770, 2012, A1. Location in patent: Page/Page column 24
[2] Patent: US2004/6076, 2004, A1. Location in patent: Page 15
[3] Journal of Organic Chemistry, 2013, vol. 78, # 13, p. 6427 - 6439 |
| | 2-Fluorophenylboronic acid Preparation Products And Raw materials |
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