BAM-22P (8-22) (human, mouse, rat, bovine) (trifluoroacetate salt)

Request For Quotation
BAM-22P (8-22) (human, mouse, rat, bovine) (trifluoroacetate salt) Suppliers list
Company Name: Cayman Chemical Company  
Tel: 800-364-9897
Email: sales@caymanchem.com
Company Name: Neobioscience Co., Ltd.  
Tel: 4006-800-892
Email: info@neobioscience.com
BAM-22P (8-22) (human, mouse, rat, bovine) (trifluoroacetate salt) Basic information
Product Name:BAM-22P (8-22) (human, mouse, rat, bovine) (trifluoroacetate salt)
Synonyms:BAM-22P (8-22) (human, mouse, rat, bovine) (trifluoroacetate salt)
CAS:
MF:
MW:0
EINECS:
Product Categories:
Mol File:Mol File
BAM-22P (8-22) (human, mouse, rat, bovine) (trifluoroacetate salt) Structure
BAM-22P (8-22) (human, mouse, rat, bovine) (trifluoroacetate salt) Chemical Properties
solubility Water: 1mg/ml
Safety Information
MSDS Information
BAM-22P (8-22) (human, mouse, rat, bovine) (trifluoroacetate salt) Usage And Synthesis
DescriptionBAM-22P (8-22) is an endogenous neuropeptide derived from proenkephalin A and an agonist of MAS-related G protein-coupled receptor family member X1 (MRGPRX1), previously known as sensory neuron-specific G protein-coupled receptor 4 (SNSR4).1 It is involved in prurition and nociception. BAM-22P (8-22) induces calcium mobilization in HEK293S cells expressing human MRGPRX1 or SNSR3 (EC50s = 14 and 28 nM, respectively) and inhibits voltage-induced calcium currents in isolated rat neurons expressing human MRGPRX1 (EC50 = 0.6 µM).2 Intrathecal administration of BAM-22P (8-22) (30 nmol/animal) decreases the tail-flick latency in rats stimulated with the Gαi inhibitor pertussin toxin and increases the tail-flick latency in rats stimulated with the phospholipase C (PLC) inhibitor U-73122, indicating changes in pain sensitivity.3 BAM-22P (8-22) (100 µg/animal) increases scratching behavior in wild-type mice and enhances bile-duct ligation-induced scratching behavior in a mouse model of cholestasis.4WARNING This product is not for human or veterinary use.
References[1] PAOLA M.C. LEMBO. Proenkephalin A gene products activate a new family of sensory neuron–specific GPCRs[J]. Nature neuroscience, 2002, 5 3: 201-209. DOI: 10.1038/nn815
[2] HUANMIAN CHEN  Stephen R I. Modulation of ion channels and synaptic transmission by a human sensory neuron-specific G-protein-coupled receptor, SNSR4/mrgX1, heterologously expressed in cultured rat neurons.[J]. Journal of Neuroscience, 2004, 24 21: 5044-5053. DOI: 10.1523/jneurosci.0990-04.2004
[3] TINGJUN CHEN  Yanguo H  Dongmei Wang. Dual modulation effects of Mas-related gene (Mrg) receptors on pain sensitivity in rats[J]. Neuroscience Letters, 2012, 514 1: Pages 82-85. DOI: 10.1016/j.neulet.2012.02.062
[4] BABINA SANJEL W S H Maeng. BAM8-22 and its receptor MRGPRX1 may attribute to cholestatic pruritus[J]. Scientific Reports, 2019. DOI: 10.1038/s41598-019-47267-5
BAM-22P (8-22) (human, mouse, rat, bovine) (trifluoroacetate salt) Preparation Products And Raw materials
Tag:BAM-22P (8-22) (human, mouse, rat, bovine) (trifluoroacetate salt) Related Product Information
Orexin A (17-33) (human, mouse, rat, bovine) (trifluoroacetate salt) Orexin A amide (bovine, human, mouse, rat) (trifluoroacetate salt) BAM-22P (human, mouse, rat, bovine) (trifluoroacetate salt) γ1-MSH (human, mouse, rat, bovine) (trifluoroacetate salt) Galanin (2-11) amide (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)