4-Methanesulfonyl-piperidine manufacturers
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| | 4-Methanesulfonyl-piperidine Basic information |
| Product Name: | 4-Methanesulfonyl-piperidine | | Synonyms: | EOS-61037;4-Methanesulfonyl-piperidine;4-(methylsulfonyl)piperidine hydrochloride;4-(Methylsulfonyl)piperid...;4-Methanesulfonylpiperidine hydrochloride;Piperidine, 4-(Methylsulfonyl)- | | CAS: | 290328-55-1 | | MF: | C6H13NO2S | | MW: | 163.24 | | EINECS: | 1533716-785-6 | | Product Categories: | | | Mol File: | 290328-55-1.mol |  |
| | 4-Methanesulfonyl-piperidine Chemical Properties |
| Boiling point | 336.9±31.0 °C(Predicted) | | density | 1.18±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | pka | 9.22±0.10(Predicted) | | Appearance | White to off-white Solid |
| | 4-Methanesulfonyl-piperidine Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 4-methylsulfonylpiperidine from tert-butyl 4-(methylsulfonyl)piperidine-1-carboxylate (Step 4): tert-butyl 4-(methylsulfonyl)piperidine-1-carboxylate obtained in Step 3 of Reference Example 12 was dissolved in ethyl acetate (16 mL), followed by the addition of a 4.0 mol/L dioxane solution of hydrogen chloride (12 mL). The reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, the precipitated solid was collected by filtration to afford the target product 4-(methylsulfonyl)piperidine (1.4 g, 76% yield). The structure of the product was confirmed by 1H-NMR (DMSO-d6, 270 MHz) with the following chemical shifts δ (ppm): 3.41-3.31 (m, 3H), 2.97 (s, 3H), 2.97-2.82 (m, 2H), 2.18-2.13 (m, 2H), 1.92-1.73 (m, 2H). | | References | [1] Patent: EP1642880, 2006, A1. Location in patent: Page/Page column 112
[2] Patent: US2003/100567, 2003, A1 |
| | 4-Methanesulfonyl-piperidine Preparation Products And Raw materials |
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