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| | Cyclohexanecarboxylic acid chloride Basic information |
| | Cyclohexanecarboxylic acid chloride Chemical Properties |
| Hazard Codes | C | | Risk Statements | 34-37-22 | | Safety Statements | 26-28-36/37/39-45 | | RIDADR | UN 3265 8/PG 2 | | WGK Germany | 1 | | F | 9-19-21 | | TSCA | TSCA listed | | HazardClass | 8 | | PackingGroup | II | | HS Code | 29162000 | | Storage Class | 8A - Combustible corrosive hazardous materials | | Hazard Classifications | Acute Tox. 4 Oral
Eye Dam. 1
Skin Corr. 1B
STOT SE 3 | | Toxicity | LD50 orally in Rabbit: 965 mg/kg |
| | Cyclohexanecarboxylic acid chloride Usage And Synthesis |
| Chemical Properties | clear colourless to straw coloured liquid | | Uses | Cyclohexanecarbonyl chloride is used in the preparation of five thiourea derivative ligands having anti-bacterial and anti-yeast activity, (N-(diethylcarbamothioyl)cyclohexanecarboxamide, N-(di-n-propylcarbamothioyl)cyclohexanecarboxamide, di-n-butylcarbamothioyl)cyclohexanecarboxamide, N-(diphenylcarbamothioyl)cyclohexanecarboxamide, N-(morpholine-4-carbonothioyl)cyclohexanecarboxamide. | | General Description | Electrochemical reduction of cyclohexanecarbonyl chloride at a hanging mercury drop electrode in acetonitrile has been reported. | | Synthesis | The general procedure for the synthesis of cyclohexanecarboxylic acid from cyclohexanecarboxylic acid is as follows: 20.0 g (of which 6.95 g, 0.054 mol, of cyclohexanecarboxylic acid) of cyclohexanecarboxylic acid solution was added to 1.0 g of n-dodecane (as an internal standard) to a reactor fitted with a condenser and a Dean-Stark water separator. After adding 90 mL of benzene, about 25 mL of benzene was removed by distillation under nitrogen protection to prepare an anhydrous solution. After the reaction solution was cooled to room temperature, 6.0 mL (9.8 g, 0.082 mol) of thionyl chloride was added and the reaction was refluxed for 1 hour. After completion of the reaction, a portion of the reaction solution was taken and reacted with methanol containing a small amount of triethylamine, which was used to identify the product cyclohexanecarbonyl chloride. The yield of methyl cyclohexanecarboxylate was analyzed by gas chromatography (GC). The results showed that the conversion of cyclohexanecarboxylic acid chloride was more than 99% and the selectivity was higher than 99%. | | References | [1] Patent: US2004/73068, 2004, A1. Location in patent: Page 3
[2] Patent: US2004/73068, 2004, A1. Location in patent: Page 4
[3] Canadian Journal of Chemistry, 1996, vol. 74, # 12, p. 2401 - 2412
[4] Organic Syntheses, 1983, vol. 61, p. 134 - 134 |
| | Cyclohexanecarboxylic acid chloride Preparation Products And Raw materials |
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