- 3-Aminoacetophenone
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- $100.00/ kg
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2026-04-28
- CAS:99-03-6
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 5000
- 3-Aminoacetophenone
-
- $10.00 / 1kg
-
2026-03-20
- CAS:99-03-6
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 10 mt
- 3-Aminoacetophenone
-
- $0.00 / 1KG
-
2025-12-24
- CAS:99-03-6
- Min. Order: 1KG
- Purity: 99.0%
- Supply Ability: 1000KG
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| | 3-Aminoacetophenone Basic information |
| | 3-Aminoacetophenone Chemical Properties |
| Melting point | 94-98 °C(lit.) | | Boiling point | 289-290 °C(lit.) | | density | 1.1031 (rough estimate) | | vapor pressure | 1.319Pa at 25℃ | | refractive index | 1.5700 (estimate) | | Fp | 289-291°C | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | | pka | 3.41±0.10(Predicted) | | form | Solid | | color | Yellow to light brown crystalline powder | | Water Solubility | 7.056g/L(37.5 ºC) | | Merck | 14,413 | | BRN | 386009 | | InChI | 1S/C8H9NO/c1-6(10)7-3-2-4-8(9)5-7/h2-5H,9H2,1H3 | | InChIKey | CKQHAYFOPRIUOM-UHFFFAOYSA-N | | SMILES | CC(=O)c1cccc(N)c1 | | LogP | 0.83 | | CAS DataBase Reference | 99-03-6(CAS DataBase Reference) | | NIST Chemistry Reference | 3-Aminoacetophenone(99-03-6) | | EPA Substance Registry System | 3-Aminoacetophenone (99-03-6) |
| Hazard Codes | Xn,Xi | | Risk Statements | 22-36/37/38 | | Safety Statements | 36/37-36-26 | | WGK Germany | 2 | | RTECS | AM5800000 | | TSCA | TSCA listed | | HazardClass | IRRITANT | | HS Code | 29223900 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral |
| | 3-Aminoacetophenone Usage And Synthesis |
| Chemical Properties | 3-Aminoacetophenone is yellow to light brown crystalline powder | | Uses | 3'-Aminoacetophenone has potential anti-bacterial properties in addition to being used in the synthesis of selective antagonists at human A2B adenosine receptors. As well, it is used in the synthesis
of HIV-1 Integrase Inhibitors. | | Uses | 3′-Aminoacetophenone (3-Acetylaniline) was used as reagent during the asymmetric total synthesis of pactamycin. It was used as starting reagent during the synthesis of curcumin mimics with substituted sulfonyl group. | | Definition | ChEBI: 3'-Aminoacetophenone is an aromatic ketone. | | Synthesis Reference(s) | Synthetic Communications, 26, p. 973, 1996 DOI: 10.1080/00397919608003701 | | General Description | 3′-Aminoacetophenone acts as bifunctional coupling reagent during the synthesis of pyrimidines. | | Safety Profile | Moderately toxic by ingestion. Mddly toxic by skin contact. A skin and eye irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of NO,. See also AROMATIC AMINES. | | Synthesis | Add 2.0g of m-nitroacetophenone, 0.2g of Pt/Bi2O3 (Pt content 0.2 wt%), 10mL of anhydrous methanol into a 50mL intermittent reactor, successively replace the gas in the reactor with nitrogen and hydrogen for 3-5 times, fill with hydrogen to a pressure of 1.0MPa, and raise the temperature to 70C with constant stirring, stirring speed of 600-800rpm. If the total pressure drops to below 0.5MPa, supplement hydrogen to the initial pressure. If the total pressure dropped below 0.5 MPa, hydrogen was replenished to the initial pressure. after 4 h the total pressure did not change, stirring was stopped and the mixture was cooled to room temperature. Centrifugation of the reaction mixture, the bottom of the yellow catalyst, the supernatant is green (if the conversion of m-nitroacetophenone is incomplete, the supernatant is yellow-green, by-products have nitro partial hydrogenation products nitroso compounds). A small amount of supernatant was analyzed by gas chromatography, and the conversion rate of m-nitroacetophenone was more than 99.9%, and the selectivity of m-aminoacetophenone was more than 99.9%. After the methanol in the filtrate was removed by rotary evaporation, m-aminoacetophenone was obtained, and the separation yield was 99%. | | Purification Methods | Recrystallise it from EtOH or aqueous EtOH (m 99.5o). The thiosemicarbazone has m 202-204o (from EtOH). [Beilstein 14 H 45, 14 IV 96.] |
| | 3-Aminoacetophenone Preparation Products And Raw materials |
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