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| | 6-Hydroxy-5-nitro-2-picoline Basic information |
| | 6-Hydroxy-5-nitro-2-picoline Chemical Properties |
| Melting point | 225-226 C | | Boiling point | 277.46°C (rough estimate) | | density | 1.4564 (rough estimate) | | refractive index | 1.5100 (estimate) | | storage temp. | Inert atmosphere,Room Temperature | | pka | 8.47±0.10(Predicted) | | form | powder to crystal | | color | Light yellow to Brown to Dark green | | InChI | 1S/C6H6N2O3/c1-4-2-3-5(8(10)11)6(9)7-4/h2-3H,1H3,(H,7,9) | | InChIKey | YVYDGIGILRUPED-UHFFFAOYSA-N | | SMILES | Cc1ccc(c(O)n1)[N+]([O-])=O | | CAS DataBase Reference | 39745-39-6(CAS DataBase Reference) |
| Hazard Codes | Xi,Xn | | Risk Statements | 36/37/38-41-37/38-22 | | Safety Statements | 37/39-26-36-39 | | WGK Germany | 3 | | Hazard Note | Irritant | | HS Code | 29337900 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
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ACROS
| English |
| | 6-Hydroxy-5-nitro-2-picoline Usage And Synthesis |
| Chemical Properties | Yellow crystalline powder | | Uses | 2-Hydroxy-6-methyl-3-nitropyridine is a water soluble compound that has been used for the treatment of tuberculosis. | | Synthesis | Synthesis of 2-hydroxy-3-nitro-6-methylpyridine: 2-amino-3-nitro-6-methylpyridine (10 g, 0.065 mol) was added to 100 mL of water, and concentrated sulfuric acid (12 mL) was added slowly under stirring and cooled to 0 °C in an ice bath. Sodium nitrite (6.9 g, 0.098 mol) was added in batches, and the reaction temperature was maintained at 0 °C for 4 h, followed by a 12 h standing time. A large amount of yellow precipitate precipitated during the reaction, the precipitate was collected by filtration under reduced pressure and dried under vacuum to give 7.7 g of yellow target product in 77% yield. The melting point of the product was 216.5-218.5 °C (water). | | References | [1] Patent: EP2366691, 2011, A1. Location in patent: Page/Page column 11
[2] Journal of the American Chemical Society, 1952, vol. 74, p. 3828,3830 |
| | 6-Hydroxy-5-nitro-2-picoline Preparation Products And Raw materials |
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