IRISQUINONE manufacturers
- IRISQUINONE USP/EP/BP
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- $1.10
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2026-08-20
- CAS:56495-82-0
- Min. Order: 1g
- Purity: 99.9%
- Supply Ability: 100 Tons Min
- Irisquinone
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2020-05-03
- CAS:56495-82-0
- Min. Order: 1KG
- Purity: 99.0%
- Supply Ability: 800 ton
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| | IRISQUINONE Basic information |
| Product Name: | IRISQUINONE | | Synonyms: | 2-(10-heptadecenyl)-6-methoxy-5-cyclohexadiene- (z)-4-dione;2-(10-heptadecenyl)-6-methoxy-5-cyclohexadiene-(z)-4-dione;6-methoxy-2-delta(sup 10')-cis-heptadecenyl-1,4-benzoquinone;pallasone;2-[(Z)-10-Heptadecenyl]-6-methoxy-2,5-cyclohexadiene-1,4-dione;Irisquinone A;IRISQUINONE;2,5-Cyclohexadiene-1,4-dione, 2-(10Z)-10-heptadecen-1-yl-6-methoxy- | | CAS: | 56495-82-0 | | MF: | C24H38O3 | | MW: | 374.56 | | EINECS: | | | Product Categories: | | | Mol File: | 56495-82-0.mol |  |
| | IRISQUINONE Chemical Properties |
| Melting point | 40-43 °C | | Boiling point | 483.4±34.0 °C(Predicted) | | density | 0.97±0.1 g/cm3(Predicted) | | LogP | 8.850 (est) |
| | IRISQUINONE Usage And Synthesis |
| Uses | Irisquinone, a natural product, is an anticancer agent. Irisquinone is also a radiation sensitizer for cancer. Irisquinone reduces GSH level and inhibits the repair of DNA singular strand breaks[1][2][3]. | | in vivo | Irisquinone (12.5 mg/kg, perfused daily) makes the rabbit VX2 lung transplant tumor wall thinner and the necrotic area larger in the irisquinone + radiotherapy group[1].
| Animal Model: | Rabbit bearing VX2 lung transplant tumor[1] | | Dosage: | 12.5 mg/kg | | Administration: | Perfused daily, starting from 3 days before irradiation to the end of irradiation. | | Result: | Displayed no significant difference of tumor growth between the radio therapy and Irisquinone + radiotherapy groups.
Showed thinner tumor wall and the larger necrotic area in the Irisquinone + radiotherapy group. |
| | References | [1] Xu H, et al. Dynamic observation of the radiosensitive effect of irisquinone on rabbit VX2 lung transplant tumors by using fluorine-18-deoxyglucose positron emission tomography/computed tomography. Nucl Med Commun. 2013 Mar;34(3):220-8. DOI:10.1097/MNM.0b013e32835d3730
[2] Wang H, et al. Radiosensitizing effect of irisquinone on glioma through the downregulation of HIF-1α evaluated by 18F-FDG and 18F-FMISO PET/CT. Nucl Med Commun. 2016 Jul;37(7):705-14. DOI:10.1097/MNM.0000000000000498
[3] Liang, l., et al. The effect of Irisquinone on the glutathione system and MRP expression of cisplatin-resistant human lung adenocarcinoma cell line (A DDP549). Chin J Cancer Res 13, 171–175 (2001). |
| | IRISQUINONE Preparation Products And Raw materials |
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