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| | 2-THIENYL-2-DIMETHYLAMINOETHYL KETONE HCL Basic information |
| Product Name: | 2-THIENYL-2-DIMETHYLAMINOETHYL KETONE HCL | | Synonyms: | SALOR-INT L158135-1EA;2-THIENYL-2-DIMETHYLAMINOETHYL KETONE HCL;3-(DIMETHYLAMINO)-1-(THIOPHEN-2-YL)PROPAN-1-ONE HYDROCHLORIDE;3-DiMethylaMino-1-(2-thienyl)-1-propanone hydrochloride, 97+%;3-DIMETHYLAMINO-1-(2-THIENYL)-1-PROPANONE HCl;2-Thienyl-2-dimethylaminoethyl ketone hydrochloride;2-[3-(Dimethylamino)propionyl]thiophene Hydrochloride;1-Propanone-3-(diMethylaMino)-1-(2-thienyl)- hydrochloride | | CAS: | 5424-47-5 | | MF: | C9H14ClNOS | | MW: | 219.73 | | EINECS: | 611-117-7 | | Product Categories: | | | Mol File: | 5424-47-5.mol |  |
| | 2-THIENYL-2-DIMETHYLAMINOETHYL KETONE HCL Chemical Properties |
| Melting point | 176.0 to 182.0 °C | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | soluble in Methanol | | form | powder to crystal | | color | White to Almost white | | InChI | InChI=1S/C9H13NOS.ClH/c1-10(2)6-5-8(11)9-4-3-7-12-9;/h3-4,7H,5-6H2,1-2H3;1H | | InChIKey | HPVHJPMLORARSR-UHFFFAOYSA-N | | SMILES | C1(SC=CC=1)C(=O)CCN(C)C.Cl |
| | 2-THIENYL-2-DIMETHYLAMINOETHYL KETONE HCL Usage And Synthesis |
| Uses | 3-(Dimethylamino)-1-(2-thienyl)-1-propanone, HCl | | Synthesis | 2-Acetylthiophene (128 g, 1.00 mol), dimethylamine hydrochloride (90 g, 1.10 mol), paraformaldehyde (41 g, 1.40 mol), concentrated hydrochloric acid (5 mL), and isopropanol (500 mL) were mixed and heated and refluxed for 6 hours according to the method reported by Robertson [1]. Upon completion of the reaction, the reaction solution was cooled to 0 °C and stirring was continued for 1 hour. Subsequently, the reaction mixture was filtered, the solid product was washed with cold isopropanol and finally dried at 50 °C for 16 h to give 3-dimethylamino-1-(thiophen-2-yl)-propan-1-one hydrochloride (2a). | | References | [1] Bioorganic Chemistry, 2016, vol. 65, p. 82 - 89
[2] Patent: CN104829587, 2017, B. Location in patent: Paragraph 0050-0052
[3] Tetrahedron Letters, 1990, vol. 31, # 45, p. 7101 - 7104
[4] Patent: EP2305669, 2011, A1. Location in patent: Page/Page column 1.1
[5] Organic Process Research and Development, 2006, vol. 10, # 5, p. 905 - 913 |
| | 2-THIENYL-2-DIMETHYLAMINOETHYL KETONE HCL Preparation Products And Raw materials |
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