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| | Methyl 4-amino-2-methoxybenzoate Basic information |
| | Methyl 4-amino-2-methoxybenzoate Chemical Properties |
| Melting point | 155-159 °C (lit.) | | Boiling point | 339.2±22.0 °C(Predicted) | | density | 1.179±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly), Methanol (Slightly, Heated) | | form | Solid | | pka | 2.04±0.10(Predicted) | | color | White | | InChI | InChI=1S/C9H11NO3/c1-12-8-5-6(10)3-4-7(8)9(11)13-2/h3-5H,10H2,1-2H3 | | InChIKey | YUPQMVSYNJQULF-UHFFFAOYSA-N | | SMILES | C(OC)(=O)C1=CC=C(N)C=C1OC | | CAS DataBase Reference | 27492-84-8(CAS DataBase Reference) |
| Hazard Codes | Xn,Xi | | Risk Statements | 22-36/37/38-20/21/22 | | Safety Statements | 26-36-36/37/39 | | WGK Germany | 2 | | HazardClass | IRRITANT | | HS Code | 2916399090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | Methyl 4-amino-2-methoxybenzoate Usage And Synthesis |
| Chemical Properties | Grey Solid | | Uses | An intermediate in the synthesis of Metoclopramide. | | Synthesis | Methyl 2-methoxy-4-nitrobenzoate (700 mg, 3.3 mmol) was used as a raw material for a catalytic hydrogenation reaction in methanol (10 mL) with the addition of 5% Pd-C (100 mg) and Na2SO4 (100 mg) as a catalyst for 1 h at 50 psi hydrogen pressure. Upon completion of the reaction, methyl 2-methoxy-4-aminobenzoate (600 mg, quantitative yield) was obtained and the product was a white solid. | | References | [1] Patent: US2015/266828, 2015, A1. Location in patent: Paragraph 1023
[2] Patent: WO2016/53794, 2016, A1. Location in patent: Page/Page column 125
[3] Patent: WO2015/6100, 2015, A1. Location in patent: Page/Page column 176
[4] Proceedings - Indian Academy of Sciences, Section A, 1950, vol. 32, p. 357,362
[5] Journal of the American Chemical Society, 1952, vol. 74, p. 592,595 |
| | Methyl 4-amino-2-methoxybenzoate Preparation Products And Raw materials |
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