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| | 4-Dimethylaminobenzoic acid Basic information |
| | 4-Dimethylaminobenzoic acid Chemical Properties |
| Melting point | 241-243 °C (dec.)(lit.) | | Boiling point | 117-118 C | | density | 1,04 g/cm | | refractive index | 1,3715 | | Fp | 170 °C | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | pka | 6.03, 11.49(at 25℃) | | form | Crystalline Powder | | color | White, beige to grayish green | | Water Solubility | Insoluble in water. | | Merck | 14,3232 | | BRN | 386867 | | Stability: | Stable. Incompatible with strong oxidizing agents. | | Major Application | peptide synthesis | | InChI | 1S/C9H11NO2/c1-10(2)8-5-3-7(4-6-8)9(11)12/h3-6H,1-2H3,(H,11,12) | | InChIKey | YDIYEOMDOWUDTJ-UHFFFAOYSA-N | | SMILES | CN(C)c1ccc(cc1)C(O)=O | | CAS DataBase Reference | 619-84-1(CAS DataBase Reference) | | NIST Chemistry Reference | Benzoic acid, 4-(dimethylamino)-(619-84-1) | | EPA Substance Registry System | Benzoic acid, 4-(dimethylamino)- (619-84-1) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-37/39 | | WGK Germany | 3 | | RTECS | DG8735000 | | TSCA | TSCA listed | | HS Code | 29224995 | | Storage Class | 13 - Non Combustible Solids |
| | 4-Dimethylaminobenzoic acid Usage And Synthesis |
| Chemical Properties | 4-Dimethylaminobenzoic acid is light grey powder | | Uses | 4-(Dimethylamino)benzoic Acid is a substituted benzoic acid that acts as an inhibitor of ultraviolet mediated damage to skin. 4-(Dimethylamino)benzoic Acid is a biotransformation product of 2-ethylhe
xyl 4-(N,N-dimethylamino)benzoate (EDP), a widely used UV filters in sunscreen cosmetics and other cosmetic products. | | Uses | 4-Dimethylaminobenzoic acid a substituted benzoic acid that acts as an inhibitor of ultraviolet mediated damage to skin. It is a biotransformation product of 2-ethylhexyl 4- (N,N-dimethylaminobenzo)benzoate(EDP), a widely used UV filters in sunscreen cosmetics and other cosmetic products. | | Synthesis Reference(s) | The Journal of Organic Chemistry, 25, p. 1807, 1960 DOI: 10.1021/jo01080a035 | | reaction suitability | reaction type: solution phase peptide synthesis | | Synthesis | a, weigh 1g of ethyl p-aminobenzoate in a two-port round-bottomed flask, add 40 ml of acetone to dissolve, then add 3.6g of anhydrous potassium carbonate and 14.1g of iodomethane, the reaction under nitrogen protection at 80 ?? stirring reflux for 24 hours, the reaction is complete, filtration of the reaction solution, take the filtrate, extracted with dichloromethane, the organic phase dewatered with magnesium sulfate, filtration and removal of magnesium sulfate, evaporation and concentration of the product with a The product was separated and purified by chromatographic column (mobile phase dichloromethane: methanol = 20:1) to obtain the product ethyl 4-dimethylaminobenzoate. b, in step a of the proceeds of 4-dimethylaminobenzoic acid ethyl ester, add 10% sodium hydroxide, not more than the reaction can be, 95% ethanol as a solvent, reflux reaction at 85 ?? C for 6 hours, with 1M hydrochloric acid to adjust the PH to a weak acidic reaction, the reaction solution is concentrated, add anhydrous acetone to dissolve, filtration, take the precipitate, vacuum drying to get 4-dimethylaminobenzoic acid; | | Purification Methods | Crystallise the acid from EtOH/water. [Beilstein 14 IV 1164.] |
| | 4-Dimethylaminobenzoic acid Preparation Products And Raw materials |
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