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| | 3-(2-Fluorophenyl)propionic acid Basic information |
| | 3-(2-Fluorophenyl)propionic acid Chemical Properties |
| Melting point | 74-78 °C | | Boiling point | 273.7±15.0 °C(Predicted) | | density | 1.222±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | form | solid | | pka | 4.65±0.10(Predicted) | | Appearance | White to light yellow Solid | | InChIKey | GUZLQEOSDXLCKX-UHFFFAOYSA-N | | CAS DataBase Reference | 1643-26-1(CAS DataBase Reference) |
| Hazard Codes | C,Xi,Xn | | Risk Statements | 36/37/38-22 | | Safety Statements | 26-36/37/39 | | WGK Germany | 3 | | Hazard Note | Corrosive | | HazardClass | IRRITANT, CORROSIVE | | HS Code | 29163990 |
| | 3-(2-Fluorophenyl)propionic acid Usage And Synthesis |
| Chemical Properties | Off-white solid | | Synthesis | c) Preparation of 3-(2-fluorophenyl)propionic acid
A mixture of ethyl 3-(2-fluorophenyl)propionate (25.54 g, 0.130 mol) with 50% aqueous sodium hydroxide solution (30 mL) in water (130 mL) was refluxed for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently washed with ether (2 x 100 mL) to remove organic impurities. The aqueous phase was cooled in an ice bath and the pH was adjusted to 3 by slow dropwise addition of hydrochloric acid to promote precipitation of 3-(2-fluorophenyl)propionic acid. The white precipitate formed was collected by filtration and washed several times with water to remove residual inorganic salts. Finally, the product was dried under vacuum at 60 °C for 18 h to afford 18.66 g (85% yield) of 3-(2-fluorophenyl)propionic acid as a white solid with a melting point of 72°-74 °C. The purity of the product met the requirements for subsequent use without further purification. | | References | [1] Patent: US5872118, 1999, A |
| | 3-(2-Fluorophenyl)propionic acid Preparation Products And Raw materials |
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