|
|
| | 3-Fluoro-4-methoxyaniline Basic information |
| | 3-Fluoro-4-methoxyaniline Chemical Properties |
| Melting point | 81-83 °C (lit.) | | Boiling point | 135 °C/18 mmHg (lit.) | | density | 1.1382 (estimate) | | Fp | >110°C | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly), Methanol (Slightly) | | pka | 4.18±0.10(Predicted) | | form | Crystalline Powder | | color | Light beige to yellow-brown | | BRN | 2717083 | | InChI | InChI=1S/C7H8FNO/c1-10-7-3-2-5(9)4-6(7)8/h2-4H,9H2,1H3 | | InChIKey | LJWAPDSCYTZUJU-UHFFFAOYSA-N | | SMILES | C1(N)=CC=C(OC)C(F)=C1 | | CAS DataBase Reference | 366-99-4(CAS DataBase Reference) |
| | 3-Fluoro-4-methoxyaniline Usage And Synthesis |
| Chemical Properties | light beige to yellow-brown crystalline powder | | Uses | 3-Fluoro-4-methoxyaniline was used as a reagent in the synthesis of novel leucine ureido derivatives which have potent inhibitory activity againt aminopeptidase N. Also used in the synthesis of novel mGluR1 antagonists for the treatment of chronic pain. | | General Description | Arrhenius parameter has been measured for the reactions of 3-fluoro-p-anisidine (3-fluoro-4-methoxyaniline) with picryl chloride. | | Synthesis | General procedure for the synthesis of 3-fluoro-4-methoxyaniline from 2-fluoro-4-nitroanisole: 3-fluoro-4-methoxynitrobenzene (0.5 g, 2.9 mmol) was dissolved in ethyl acetate (10 mL), a carbon-loaded palladium catalyst (50 mg) was added, and the reaction was stirred for 1 h at room temperature. After completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to afford the target product 3-fluoro-4-methoxyaniline (7B) as an off-white solid (0.4 g, 98% yield). | | References | [1] Journal of Medicinal Chemistry, 2000, vol. 43, # 24, p. 4701 - 4710
[2] Patent: CN104395312, 2016, B. Location in patent: Paragraph 0640-0645
[3] Patent: US2006/128729, 2006, A1. Location in patent: Page/Page column 77
[4] Patent: WO2017/129796, 2017, A1. Location in patent: Page/Page column 251; 252
[5] Journal of the American Chemical Society, 1941, vol. 63, p. 609 |
| | 3-Fluoro-4-methoxyaniline Preparation Products And Raw materials |
|