AURORA KINASE INHIBITOR III
| 中文名称 | AURORA KINASE INHIBITOR III |
|---|---|
| 中文同义词 | 化合物AURORA KINASE INHIBITOR III;N-(3-((4-((3-(三氟甲基)苯基)氨基)嘧啶-2-基)氨基)苯基)环丙烷甲酰胺;化合物AURORA KINASE INHIBITOR III,10 MM DMSO 溶液;极光激酶抑制剂III |
| 英文名称 | Aurora Kinase Inhibitor III |
| 英文同义词 | Aurora Kinase Inhibitor III;Cyclopropanecarboxylic acid {3-[4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino]-phenyl}-amide;N-[3-[[4-[3-(trifluoromethyl)anilino]pyrimidin-2-yl]amino]phenyl]cyclopropanecarboxamide;AKI-7169;Aurora Kinase Inhibitor III - CAS 879127-16-9 - Calbiochem;Aurora Kinase Inhibitor 3;Cyclopropanecarboxamide, N-[3-[[4-[[3-(trifluoromethyl)phenyl]amino]-2-pyrimidinyl]amino]phenyl]-;Cyclopropanecarboxylic acid {3-[4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino]-phenyl}-amide >=98% (HPLC), solid |
| CAS号 | 879127-16-9 |
| 分子式 | C21H18F3N5O |
| 分子量 | 413.4 |
| EINECS号 | |
| 相关类别 | 抑制剂 |
| Mol文件 | 879127-16-9.mol |
| 结构式 |  |
AURORA KINASE INHIBITOR III 性质
| 密度 | 1.456±0.06 g/cm3(Predicted) |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | H2O：<2毫克/毫升 |
| 酸度系数(pKa) | 14.51±0.70(Predicted) |
| 形态 | 白色固体 |
| 颜色 | 白色 |
| 水溶解性 | H2O: <2mg/mL DMSO: >7mg/mL |
| InChI | 1S/C21H18F3N5O/c22-21(23,24)14-3-1-4-15(11-14)26-18-9-10-25-20(29-18)28-17-6-2-5-16(12-17)27-19(30)13-7-8-13/h1-6,9-13H,7-8H2,(H,27,30)(H2,25,26,28,29) |
| InChIKey | RDTDWGQDFJPTPD-UHFFFAOYSA-N |
| SMILES | FC(F)(F)c1cccc(Nc2ccnc(Nc3cccc(NC(=O)C4CC4)c3)n2)c1 |
Aurora kinase inhibitor III是有效的Aurora A kinase抑制剂，IC50为42 nM。它对BMX, BTK, IGF-1R, c-Src, TRKB, SYK和EGFR分别为386, 3550, 591, 1980, 2510, 887和>10,000 nM。
| Target | Value |
|
Aurora A
(Cell-free assay) | 42 nM |
|
BMX
(Cell-free assay) | 386 nM |
|
IGF-1R
(Cell-free assay) | 591 nM |
|
SYK
(Cell-free assay) | 887 nM |
|
c-Src
(Cell-free assay) | 1980 nM |
安全信息
| WGK Germany | 3 |
|---|---|
| 存储类别 | 13 - 不可燃性固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/03/03 | S2931 | AURORA KINASE INHIBITOR III Aurora Kinase Inhibitor III | 879127-16-9 | 2mg | 876.61元 |
| 2026/03/03 | S2931 | AURORA KINASE INHIBITOR III Aurora Kinase Inhibitor III | 879127-16-9 | 5mg | 1777.26元 |