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| | 1-PYRIDIN-3-YL-ETHYLAMINE Basic information |
| Product Name: | 1-PYRIDIN-3-YL-ETHYLAMINE | | Synonyms: | 3-(1-aminoethyl)pyridine;alpha-methyl-3-pyridinemethylamin;1-(3-Pyridyl)ethylamine, 96%;3-Pyridinemethylamine, alpha-methyl-;alpha-Methyl-3-pyridinemethylamine;Brn 0110124;1-pyridin-3-ylethanamine (racemic-);1-(3-pyridinyl)ethanamine | | CAS: | 56129-55-6 | | MF: | C7H10N2 | | MW: | 122.17 | | EINECS: | | | Product Categories: | | | Mol File: | 56129-55-6.mol |  |
| | 1-PYRIDIN-3-YL-ETHYLAMINE Chemical Properties |
| Melting point | 63 °C | | Boiling point | 118-120 °C(Press: 14 Torr) | | density | 1.014 g/cm3(Temp: 25 °C) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | form | liquid | | pka | 8.81±0.29(Predicted) | | color | Colourless | | Sensitive | Air Sensitive | | InChI | 1S/C7H10N2/c1-6(8)7-3-2-4-9-5-7/h2-6H,8H2,1H3 | | InChIKey | IQVQNBXPYJGNEA-UHFFFAOYSA-N | | SMILES | NC(C)c1cnccc1 | | CAS DataBase Reference | 56129-55-6(CAS DataBase Reference) |
| Hazard Codes | T,Xi | | Risk Statements | 25-41-43-37/38 | | Safety Statements | 26-36/37/39-45-39 | | RIDADR | UN2735 | | WGK Germany | 3 | | HazardClass | 8 | | PackingGroup | III | | HS Code | 2933399990 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral
Eye Dam. 1
Skin Sens. 1 |
| | 1-PYRIDIN-3-YL-ETHYLAMINE Usage And Synthesis |
| Uses |
1-pyridin-3-ylethanamine is mainly used in scientific research experiments.
| | Synthesis | General procedure for the synthesis of 1-(3-pyridyl)ethylamine from 3-acetylpyridine:
1. 3-Acetylpyridine (0.5 g, 4.1 mmol), potassium carbonate (1.7 g, 12.3 mmol), hydroxylamine hydrochloride (342 mg, 5 mmol), and methanol (10 mL) were mixed and the reaction was stirred for 16 hours at room temperature.
2. After completion of the reaction, the mixture was filtered and the filtrate was collected.
3. Zinc powder (1.3 g, 21 mmol) and ammonium chloride (1.1 g, 21 mmol) were added to the filtrate and stirring was continued at room temperature for 24 hours.
4. At the end of the reaction, water (10 mL) was added to the reaction mixture and filtered again.
5. The filtrate was concentrated and dried to give the white solid product 1-(3-pyridyl)ethylamine in 300 mg yield and 60% yield.
Product characterization data:
1H NMR (300 MHz, DMSO-d6) δ 8.52 (d, J = 4.9 Hz, 1H), 8.32 (td, J = 7.7, 1.9 Hz, 1H), 7.68 (d, J = 7.7 Hz, 1H), 7.28 (ddd, J = 7.5, 4.9, 1.1 Hz, 1H), 4.6 (q, J = 6.0 Hz, 1H) , 1.25 (d, J = 6.6 Hz, 3H); MS (ESI) m/z 123.4 [M + 1]+. | | References | [1] Patent: WO2008/51493, 2008, A2. Location in patent: Page/Page column 105
[2] Patent: WO2003/99776, 2003, A1. Location in patent: Page 94-95
[3] Journal of the American Chemical Society, 1944, vol. 66, p. 1293
[4] Patent: WO2006/110668, 2006, A1. Location in patent: Page/Page column 54
[5] Patent: WO2009/42694, 2009, A1. Location in patent: Page/Page column 66 |
| | 1-PYRIDIN-3-YL-ETHYLAMINE Preparation Products And Raw materials |
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