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| | 5-[(2-Hydroxyethyl)amino]-o-cresol Basic information |
| Product Name: | 5-[(2-Hydroxyethyl)amino]-o-cresol | | Synonyms: | 2-METHYL-5-N-(BETA-HYDROXYETHYL)AMINO PHENOL;2-Methyl-5-N-hydroxyethylamino phenol;5-[(2-HYDROXYETHYL)AMINO]-O-CRESOL;5[(2-HYDROXYETHYL)AMINO]-2-METHYL PHENOL;1-methyl-2-hydroxy-4-(beta-hydroxyethyl)aminobenzene;5-((2-hydroxyethyl)amino)-2-methyl-pheno;6-methyl-3-beta-hydroxyethylaminophenol;N-HydroxyethylAmino-O-Cresol | | CAS: | 55302-96-0 | | MF: | C9H13NO2 | | MW: | 167.21 | | EINECS: | 259-583-7 | | Product Categories: | | | Mol File: | 55302-96-0.mol | ![5-[(2-Hydroxyethyl)amino]-o-cresol Structure](CAS/GIF/55302-96-0.gif) |
| | 5-[(2-Hydroxyethyl)amino]-o-cresol Chemical Properties |
| Melting point | 90-92℃ | | Boiling point | 366.0±32.0 °C(Predicted) | | density | 1+-.0.06 g/cm3(Predicted) | | vapor pressure | 0.004Pa at 20℃ | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Solid | | pka | 10.28±0.10(Predicted) | | color | Light Beige | | Water Solubility | 37g/L at 20℃ | | Cosmetics Ingredients Functions | HAIR DYEING
COLORANT | | Cosmetic Ingredient Review (CIR) | 5-[(2-Hydroxyethyl)amino]-o-cresol (55302-96-0) | | LogP | 0.772 at 23℃ | | CAS DataBase Reference | 55302-96-0(CAS DataBase Reference) |
| | 5-[(2-Hydroxyethyl)amino]-o-cresol Usage And Synthesis |
| Chemical Properties | Light brown powder | | Uses | 5-[(2-Hydroxyethyl)amino]-o-cresol is a substance present as an aminophenol component in hair dyes (especially oxidative hair dyes) and detected accordingly[2]. | | Flammability and Explosibility | Not classified | | Synthesis | In a 250 mL four-necked flask fitted with a thermometer and stirrer, 12.3 g (0.1 mol) of 5-amino-2-methylphenol was dissolved in 80 mL of diethylene glycol dimethyl ether and heated to 150 °C. Under slow stirring in a cold trap, 4.4 g (0.1 mol) of ethylene oxide was dissolved in 10 mL of diethylene glycol dimethyl ether and 0.3 g of NaY molecular sieve catalyst was added to a four-necked flask, followed by dropwise addition of the mixture. After the dropwise addition process lasted for 0.5 hr, the reaction was continued for 3 hr. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure, dried and the residue was cooled to give 16.6 g of 5-(2-hydroxyethyl)amino-o-cresol crude product. The crude product was dissolved in 100 mL of methanol-water mixed solvent and recrystallized to give 15.7 g of refined 5-(2-hydroxyethyl)amino-o-cresol in 94.1% yield and 99.52% purity. | | References | [1] Patent: CN106588678, 2017, A. Location in patent: Paragraph 0025; 0026; 0028; 0030; 0031; 0032; 0034
[2]ZHU, W., WANG, C., YANG, J., WEI, W., SUN, Z., & ZHANG, S. (2013). Simultaneous determination of 11 aminophenols in hair dyes by high performance liquid chromatography. Chinese Journal of Chromatography, 30(9), 870–875. https://doi.org/10.3724/sp.j.1123.2012.04014 |
| | 5-[(2-Hydroxyethyl)amino]-o-cresol Preparation Products And Raw materials |
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