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| | 10-Vinyl-19-norpregn-4-ene-3,20-dione Basic information |
| | 10-Vinyl-19-norpregn-4-ene-3,20-dione Chemical Properties |
| form | Solid | | color | White to off-white |
| | 10-Vinyl-19-norpregn-4-ene-3,20-dione Usage And Synthesis |
| Uses | Org OD 02-0 (10-Ethenyl-19-norprogesterone) is a membrane progesterone receptor α (mPRα)-specific agonist (IC50: 33.9 nM). Org OD 02-0 activates MAPK activity. Org OD 02-0 inhibits prolactin (PRL) secretion in the pituitary[1][2]. | | References | [1] Kelder J, et al. Comparison between steroid binding to membrane progesterone receptor alpha (mPRalpha) and to nuclear progesterone receptor: correlation with physicochemical properties assessed by comparative molecular field analysis and identification of mPRalpha-specific agonists. Steroids. 2010 Apr;75(4-5):314-22. DOI:10.1016/j.steroids.2010.01.010
[2] Camilletti MA, et al. Participation of membrane progesterone receptor α in the inhibitory effect of progesterone on prolactin secretion. J Neuroendocrinol. 2018 Sep;30(9):e12614. DOI:10.1111/jne.12614 |
| | 10-Vinyl-19-norpregn-4-ene-3,20-dione Preparation Products And Raw materials |
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