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| | TRIFLUOROACETIC ACID HYDRAZIDE Basic information |
| Product Name: | TRIFLUOROACETIC ACID HYDRAZIDE | | Synonyms: | TRIFLUOROACETIC ACID HYDRAZIDE;2,2,2-Trifluoroacetohydrazide;Trifluoroacetyl Hydrazide;2,2,2-trifluoroAcetic acid hydrazide;Acetic acid, 2,2,2-trifluoro-, hydrazide;1,3-bis(4-nitrophenyl)-2-propanone;Trifluoroacetohydrazide, tech;Hydrazine trifluoroacetate | | CAS: | 1538-08-5 | | MF: | C2H3F3N2O | | MW: | 128.05 | | EINECS: | | | Product Categories: | | | Mol File: | 1538-08-5.mol |  |
| | TRIFLUOROACETIC ACID HYDRAZIDE Chemical Properties |
| Melting point | 111 °C | | Boiling point | 84-86 °C(Press: 14 Torr) | | density | 1.462±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | | form | solid | | pka | 9.47±0.20(Predicted) | | color | White |
| | TRIFLUOROACETIC ACID HYDRAZIDE Usage And Synthesis |
| Uses | Trifluoroacetic acid hydrazide is used in chemical synthesis applications. It is used in the preparation of sitagliptin intermediates, pyridazinone derivatives and fluoronitrocarboxylic acid hydrazides, among other organic compounds. | | Synthesis | Step 2 Preparation of trifluoroacetohydrazide: Ethyl trifluoroacetate (14.2 g, 0.10 mol) and hydrazine hydrate (5.54 g, 0.11 mol) were dissolved in ethanol (25 mL), and heated and refluxed for 6 hours. After the reaction was completed, the solvent was removed by distillation under reduced pressure, and the resulting residue was dried under vacuum to obtain trifluoroacetohydrazide (12.3 g, 96% yield), the product was a transparent oil, which was solidified after standing. | | References | [1] Patent: US6423713, 2002, B1
[2] Patent: US6514977, 2003, B1
[3] Patent: US6979686, 2005, B1. Location in patent: Page/Page column 134
[4] Magnetic Resonance in Chemistry, 1990, vol. 28, p. 331 - 336
[5] Journal of the Indian Chemical Society, 2010, vol. 87, # 5, p. 589 - 593 |
| | TRIFLUOROACETIC ACID HYDRAZIDE Preparation Products And Raw materials |
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