8,8'-Diapo-ψ,ψ-carotene-8,8'-dioic acid 8-methyl ester

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8,8'-Diapo-ψ,ψ-carotene-8,8'-dioic acid 8-methyl ester Basic information
Product Name:8,8'-Diapo-ψ,ψ-carotene-8,8'-dioic acid 8-methyl ester
Synonyms:8,8'-Diapo-ψ,ψ-carotene-8,8'-dioic acid 8-methyl ester;crocetin monomethyl ester;2,4,6,8,10,12,14-Hexadecaheptaenedioic acid, 2,6,11,15-tetramethyl-, monomethyl ester, (2E,4E,6E,8E,10E,12E,14E)- (9CI);β-Crocetin;Crocetin methylester;(2E,4E,6E,8E,10E,12E,14E)-16-Methoxy-2,6,11,15-tetramethyl-16-oxohexadeca-2,4,6,8,10,12,14-heptaenoic acid
CAS:25368-09-6
MF:C21H26O4
MW:342.43
EINECS:
Product Categories:
Mol File:25368-09-6.mol
8,8'-Diapo-ψ,ψ-carotene-8,8'-dioic acid 8-methyl ester Structure
8,8'-Diapo-ψ,ψ-carotene-8,8'-dioic acid 8-methyl ester Chemical Properties
storage temp. Store at -20°C, sealed storage, away from moisture and light
solubility Soluble in DMSO
form Solid
color Pink to red
Safety Information
MSDS Information
8,8'-Diapo-ψ,ψ-carotene-8,8'-dioic acid 8-methyl ester Usage And Synthesis
UsesCrocetin monomethyl ester, isolated from Crocus sativus, possesses anti-inflammatory, neuroprotective and antioxidant activity[1][2]. Crocetin monomethyl ester promotes clearance of amyloid-β by inducing autophagy via the STK11/LKB1-mediated AMPK pathway[4].
References[1] Tseng TH, et al. Crocetin protects against oxidative damage in rat primary hepatocytes. Cancer Lett. 1995 Oct 20;97(1):61-7. DOI:10.1016/0304-3835(95)03964-x
[2] Ahmad AS, et al. Neuroprotection by crocetin in a hemi-parkinsonian rat model. Pharmacol Biochem Behav. 2005 Aug;81(4):805-13. DOI:10.1016/j.pbb.2005.06.007
[3] Nam KN, et al. Anti-inflammatory effects of crocin and crocetin in rat brain microglial cells. Eur J Pharmacol. 2010 Dec 1;648(1-3):110-6. DOI:10.1016/j.ejphar.2010.09.003
[4] Wani A, Al Rihani SB, Sharma A, et al. Crocetin promotes clearance of amyloid-β by inducing autophagy via the STK11/LKB1-mediated AMPK pathway. Autophagy. 2021;17(11):3813-3832. DOI:10.1080/15548627.2021.1872187
8,8'-Diapo-ψ,ψ-carotene-8,8'-dioic acid 8-methyl ester Preparation Products And Raw materials
Tag:8,8'-Diapo-ψ,ψ-carotene-8,8'-dioic acid 8-methyl ester(25368-09-6) Related Product Information
Crocin trans-Crocetin (β-D-gentiobiosyl) ester Dimethylcrocetin Crocetin DisodiuM trans-crocetinate β-D-Glucopyranose, 1-[hydrogen (2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioate] 1,1'-[(2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioate]-b-D-Glucopyranose Picrocrocin 1-[(2E,4E,6E,8E,10E,12E,14E)-b-D-glucopyranosyl 2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioate] 6-O-b-D-glucopyranosyl-b-D-Glucopyranose