|
|
| | 5-Hydroxypyrazolo[1,5-a]pyrimidine Basic information |
| Product Name: | 5-Hydroxypyrazolo[1,5-a]pyrimidine | | Synonyms: | 5-Hydroxypyrazolo[1,5-a]pyrimidine;Pyrazolo[1,5-a]pyrimidin-5-ol;4H,5H-pyrazolo[1,5-a]pyriMidin-5-one;1H-pyrazolo[1,5-a]pyrimidin-5-one;pyrazolo[1,5-a]pyrimidin-5(4H)-one(WXC06578);pyrazoloapyrimidinone;Larotrectinib Impurity 6（Larotrectinib PPO Impurity）;4H,5H-pyrazolo | | CAS: | 29274-22-4 | | MF: | C6H5N3O | | MW: | 135.12 | | EINECS: | 000-000-0 | | Product Categories: | | | Mol File: | 29274-22-4.mol | ![5-Hydroxypyrazolo[1,5-a]pyrimidine Structure](CAS/GIF/29274-22-4.gif) |
| | 5-Hydroxypyrazolo[1,5-a]pyrimidine Chemical Properties |
| storage temp. | Sealed in dry,Room Temperature | | Appearance | White to off-white Solid | | InChI | InChI=1S/C6H5N3O/c10-6-2-4-9-5(8-6)1-3-7-9/h1-4H,(H,8,10) | | InChIKey | LSLIYLLMLAQRIS-UHFFFAOYSA-N | | SMILES | C12=CC=NN1C=CC(=O)N2 |
| HazardClass | IRRITANT | | HS Code | 2933998090 |
| | 5-Hydroxypyrazolo[1,5-a]pyrimidine Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of pyrazolo[1,5-a]pyrimidin-5-ol from ethyl 3-ethoxyacrylate and 3H-pyrazol-3-amine was as follows: 5-aminopyrazole (5 g, 60 mmol), ethyl 3-ethoxyacrylate (13 g, 90 mmol) and cesium carbonate (29 g, 90 mmol) were mixed in 100 ml of N,N-dimethylformamide. The reaction mixture was stirred at 110 °C overnight. After the reaction was completed, it was cooled to room temperature, diluted with 200 ml of water and then extracted with ether (40 mL x 3). The aqueous phase was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (eluent ratio of dichloromethane: methanol = 10:1) to afford 4H-pyrazolo[1,5-a]pyrimidin-5-one (8 g) in 99% yield. | | References | [1] Patent: CN104250252, 2017, B. Location in patent: Paragraph 0095; 0097; 0098
[2] Journal of Organic Chemistry, 2007, vol. 72, # 3, p. 1043 - 1046 |
| | 5-Hydroxypyrazolo[1,5-a]pyrimidine Preparation Products And Raw materials |
|