- ABT888
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- $0.00 / 1kg
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2025-09-29
- CAS:912445-05-7
- Min. Order: 1kg
- Purity: 97%
- Supply Ability: 1000
- Veliparib dihydrochloride
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- $0.00/ kg
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2024-11-26
- CAS:912445-05-7
- Min. Order: 1kg
- Purity: 99%, Single impurity＜0.1
- Supply Ability: 1 ton
Related articles - Biological activity ABT-888
- Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays.
- Oct 11，2019
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| | ABT-888 Basic information |
| Product Name: | ABT-888 | | Synonyms: | ABT-888;2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4-
carboxamide,dihydrochloridesalt;2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-4-carboxamide dihydrochloride;Veliparib dihydrochloride;ABT-888(Veliparib dihydrochloride);ABT-888 dihydrochloride;ABT888 HCl;Veliparib hydrochloride | | CAS: | 912445-05-7 | | MF: | C13H16N4O | | MW: | 244.296 | | EINECS: | 1592732-453-0 | | Product Categories: | Inhibitors;Inhibitor;API | | Mol File: | 912445-05-7.mol |  |
| | ABT-888 Chemical Properties |
| Melting point | >173°C (dec.) | | storage temp. | Refrigerator | | solubility | Methanol (Slightly, Heated), THF (Slightly, Heated) | | form | Colorless to white crystalline solid. | | color | Off-White to Dark Yellow | | InChI | InChI=1/C13H16N4O/c1-7-5-6-15-10(7)13-16-9-4-2-3-8(12(14)18)11(9)17-13/h2-4,7,10,15H,5-6H2,1H3,(H2,14,18)(H,16,17)/t7-,10?/s3 | | InChIKey | FXRVOXLVQCUUGN-IEOOLIIMNA-N | | SMILES | C1=C(C(=O)N)C2=C(NC(C3[C@H](C)CCN3)=N2)C=C1 |&1:10,r| |
| | ABT-888 Usage And Synthesis |
| Uses | ABT-888 is a potent, orally bioavailable PARP-1/-2 inhibitor shown to potentiate DNA damaging agents. The ability to potentiate temozolomide (TMZ) and develop a biological marker for PARP inhibition was evaluated in vivo. Potent PARP inhibitor. | | in vivo | The oral bioavailability of Veliparib is 56%-92% in mice, SD rats, beagle dogs, and cynomolgus monkeys after oral administration[1]. Veliparib (25 mg/kg, i.p.) can improve tumor growth delay in a NCI-H460 xenograft model. Combination with radiation, veliparib decreases the tumor vessel formation[3]. Veliparib reduces intratumor PAR levels by more than 95% at a dose of 3 and 12.5 mg/kg in A375 and Colo829 xenograft models and the suppression can be maintained over time[4]. | | IC 50 | PARP-2: 2.9 nM (Ki); PARP-1: 5.2 nM (Ki) | | storage | Store at -20°C |
| | ABT-888 Preparation Products And Raw materials |
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