Unii-8163770L8p manufacturers
- Capeserod
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- $195.00
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2026-07-27
- CAS:769901-96-4
- Purity: 99.62%
- Supply Ability: 10g
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| | Unii-8163770L8p Basic information |
| Product Name: | Unii-8163770L8p | | Synonyms: | 5-(5-amino-6-chloro-2,3-dihydro-1,4-benzodioxin-8-yl)-3-[1-(2-phenylethyl)piperidin-4-yl]-1,3,4-oxadiazol-2-one;Unii-8163770L8p;Capeserod;5-(8-AMINO-7-CHLORO-2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-3-[1-(2-PHENYLETHYL)PIPERIDIN-4-YL]-1,3,4-OXADIAZOL-2(3H)-ONE;5-(8-Amino-7-chloro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)-3-(1-phenethylpiperidin-4-yl)-1,3,4-oxad;5-(8-Amino-7-chloro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)-3-(1-phenethylpiperidin-4-yl)-1,3,4-oxadiazol-2(3H)-one;1,3,4-Oxadiazol-2(3H)-one, 5-(8-amino-7-chloro-2,3-dihydro-1,4-benzodioxin-5-yl)-3-[1-(2-phenylethyl)-4-piperidinyl]- | | CAS: | 769901-96-4 | | MF: | C23H25ClN4O4 | | MW: | 456.92 | | EINECS: | | | Product Categories: | | | Mol File: | 769901-96-4.mol |  |
| | Unii-8163770L8p Chemical Properties |
| Boiling point | 584.4±60.0 °C(Predicted) | | density | 1.47±0.1 g/cm3(Predicted) | | pka | 8.58±0.10(Predicted) | | form | Solid | | color | White to off-white |
| | Unii-8163770L8p Usage And Synthesis |
| Uses | Capeserod (SL65.0155 free base) is an agonist for serotonin receptor (5-HT receptor), with a Ki of 0.6 nM for 5-HT4 receptor. Capeserod enhances expression of phopshorilated cAMP-response element binding protein (p-CREB), vascular endothelium growth factor (VEGF), brain-derived neurotrophic factor (BDNF) and B cell lymphoma-2 (Bcl-2) proteins in hippocampus, and exhibits antidepressant-like efficacy in Wistar rats models[1]. | | IC 50 | 5-HT4 Receptor: 0.6 nM (Ki) | | References | [1] Tamburella A, et al., Antidepressant properties of the 5-HT4 receptor partial agonist, SL65.0155: behavioral and neurochemical studies in rats. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Oct 1;33(7):1205-10. DOI:10.1016/j.pnpbp.2009.07.001 |
| | Unii-8163770L8p Preparation Products And Raw materials |
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